VASCULAR ENDOTHELIAL GROWTH FACTOR AS MARKER OF VASCULAR DYSFUNCTIONS IN OBESITY CHILDREN

Authors

  • Shlyakhova N. V. SI «Institute of Children and Adolescents Health Care of the NAMS of Ukraine», Kharkiv
  • Budreyko E. A. SI «Institute of Children and Adolescents Health Care of the NAMS of Ukraine», Kharkiv
  • Chumak S. A. SI «Institute of Children and Adolescents Health Care of the NAMS of Ukraine», Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2012.1.03

Keywords:

children, obesity, vascular endothelial growth factor

Abstract

In the study was analyzed the serum level of vascular endothelial growth factor (VEGF) at 87 obesity children 9–17 years old of both sex. Significant increase of serum concentration VEGF at obesity children in comparison with healthy controls was established, especially at presence hyperinsulinemia, insulin resistance and microvasculature dysfunction, in less — at the arterial hypertension and microalbuminuria. The role of VEGF as indicator of formation of vascular dysfunctions at obesity children and adolescents on the basis of the revealed associations of its increased levels (more than 320 pg/ml and, especially, more than 450 pg/ml) with hyperinsulinemia, insulin resistance and microvasculature dysfunction was discussed.

References

The obesity pandemic: where have we been and where are we going? [Text] / J. Roth, X. Qiang, S. L. Marban [et al.] // Obes. Res. — 2004. — Vol. 12 (2). — P. 88–101.

Carmeliet, P. Angiogenesis in life, disease and medicine [Text] / P. Carmeliet // Nature. — 2005. — Vol. 438. — P. 932–936.

McDonald, D. M. Imaging of angiogenesis: from microscope to clinic [Text] / D. M. McDonald, P. L. Choyke // Nat. Med. — 2003. — Vol. 9. — P. 713–725.

Angiogenesis in adipose tissue [Text] / A. Bouloumie, K. Lolmede, C. Sengenes [et al.] // Ann. Endocrinol. (Paris). — 2002. — Vol. 63. — P. 91–95.

Ahima, R. S. Adipose tissue as an endocrine organ [Text] / R. S. Ahima // Obesity. — 2006. — Vol. 14 (5). — P. 242–249.

Neels, J. G. Angiogenesis in an in vivo model of adipose tissue development [Text] / J. G. Neels, T. Thinnes, D. J. Loskutoff // FASEB J. — 2004. — Vol. 18. — P. 983–985.

Zhu, X. Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and metaanalysis [Text] / X. Zhu, S. Wu, W. L. Dahut, C. R. Parikh // Am. J. Kidney Dis. — 2007. — Vol. 49 (2). — P. 186–193.

Evidence for a relationship between vegf and bmi independent of insulin sensitivity by glucose clamp procedure in a homogenous group healthy young men [Text] / M. Loebig, J. Klement, A. Schmoller [et al.] // PLoS One. — 2010. — Vol. 7. — 5 p.

Ferrara, N. Vascular endothelial growth factor: basic science and clinical progress [Text] / N. Ferrara //Endocrin. Rev. — 2004. — Vol. 25. — P. 581–611.

Vascular endothelial growth factor as a marker for early vascular damage in hypertension [Text] / W. C. Tsai, Y. H. Li, Y. Y. Huang [et al.] // Clin. Scin. — 2005. — Vol. 109 (1). — P. 39–43.

Involvement of serum vascular endothelial growth factor family members in the development of obesity in mice and humans [Text] / J. Gomez-Ambrosi, V. Catalan, A. Rodriguez [et al.] // J. Nutr. Biochem. — 2010. — Vol. 21 (8). — P. 774–780.

Distinct characteristics of circulating vascular endothelial growth factor-a and C levels in human subjects [Text] / H. Wada, S. Ura, S. Kitaoka [et al.] // PLoS One. — 2011. — Vol. 6 (12). — 6 p.

Elevated serum vascular endothelial growth factor is associated with visceral fat accumulation in human obese subjects [Text] / S. Miyazawa-Hoshimoto, K. Takahashi, H. Bujo [et al.] // Diabetologia. — 2003. — Vol. 46 (11). — P. 1483–1488.

Association between vascular endothelial growth factor and hypertension in children and adolescents type I diabetes mellitus [Text] / K. Zorena1, J. Mys’liwska, M. Mys’liwiec [et al.] // J. Hum. Hypert. — 2010. — Vol. 24. — P. 755–762.

Body mass index is directly associated with biomarkers of angiogenesis and inflammation in children and adolescents [Text] / M. Siervo, D. Ruggiero, R. Sorice [et al.] // Nutrition. — 2011. — Vol. 22.

Протоколи надання медичної допомоги дiтям за спецiальнiстю «Дитяча ендокринологiя» [Текст] / МОЗ України. — К.: [б. в.], 2006. — 94 с.

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man [Text] / D. R. Matthews, J. P. Hosker, A. S. Rudenski [et al.] // Diabetologia. — 1985. — Vol. 28. — P. 412–419.

Сахарный диабет и его осложнения у детей и подростков [Текст] / Филиппова Н. В., Будрейко Е. А., Никитина Л. Д. [и др.] — Х.: Основа, 2005.– 300 с.

Circulating vascular endothelial growth factor in the normo- and/or microalbuminuric patients with type 2 diabetes mellitus [Text] / P. Kubisz, P. Chudy, J. Stasko [at al.] // Act. Diabetol. — 2010. — Vol. 47 (2). — P. 119–124.

Vascular endothelial growth factor: the link between cardiovascular risk factors and microalbuminuria? [Text] / F.W. Asselbergs, R. A. de Boer, G. F. Diercks [et al.] // Int. J. Cardiol. — 2004. — Vol. 93 (2–3). — P. 211–215.

Increased vascular endothelial growth factor serum concentrations may help to identify patients with onset of type 1 diabetes during childhood at risk for developing persistent microalbuminuria [Text] / F. Santilli, A. Spagnoli, A. Mohn [et al.] // J. Clin. Endocrinol. Metabol. — 2001. — Vol. 86 (8). — P. 3871–3876.

Шляхова, Н. В. Продукцiя адипонектину та лептину у дiтей пубертатного вiку з нейроендокринним ожирiнням [Teкст] / Н. В. Шляхова, О. А. Будрейко, Д. А. Кашкалда // Укр. мед. альманах. — 2011. — Т. 14, № 4. — С. 121–124.

Insulin sensitivity, vascular reactivity, and clampinduced vasodilation in essential hypertension [Text] // A. Natali, S. Taddei, A. Quinones [et al.] // Circulation. — 1997. — Vol. 96. — P. 849–855.

Dissociation between insulin sensitivity of glucose uptake and endothelial function in normal subjects [Text] / T. Utriainen, S. Makimattila, A. Virkamaki [et al.] // Diabetologia. — 1996. — Vol. 39. — P. 1477–1482.

Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes [Text] / A. E. Caballero, S. Arora, R. Saouaf [et al.] // Diabetes. — 1999. — Vol. 48. — P. 1856–1862.

Jaap, A. J. Relationship of insulin resistance to microvascular dysfunction in subjects with fasting hyperglycemia [Text] / A. J. Jaap, A. C. Shore, J. E. Tooke // Diabetologia. — 1997. — Vol. 40. — P. 238–243.

The relationship between vascular endothelial growth factor (vegf) and microalbuminuria in patients with essential hypertension [Text] / E. F. Ayerden, E. Haksun, D. B. Ulver [et al.] // Inter. Med. — 2008. — Vol. 47. — P. 1511–1516.

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Published

2012-03-15

How to Cite

Shlyakhova, N. V., Budreyko, E. A., & Chumak, S. A. (2012). VASCULAR ENDOTHELIAL GROWTH FACTOR AS MARKER OF VASCULAR DYSFUNCTIONS IN OBESITY CHILDREN. Problems of Endocrine Pathology, 39(1), 26-32. https://doi.org/10.21856/j-PEP.2012.1.03

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Section

CLINICAL ENDOCRINOLOGY

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