STATE OF THROMBOCYTE-COAGULATION HEMOSTASIS IN RATS UNDER INFLUENCE OF METABOLITES OF SUCCINIC ACID DERIVATIVES

Authors

  • Palagina I. A. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Kudrya M. Ya. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2013.3.11

Keywords:

hemostasis, ggregation of thrombocytes, coagulation, anti-diabetic medicine metabolites

Abstract

It was found that metabolites of the first phase of biotransformation of anti-diabetic agent —
succinc acid derivative act on the various links in thrombocyte and coagulation hemostasis. The
2-hydroxyphenilsuccinamide (2-HPSA) under subchronic administration causes the inhibition of the
fibrin forming that may be a sign of anticoagulant activity of the compound. Another metabolite —
β-phenylethylsuccinamide (β-PESA) is able to enhance aggregation of thrombocytes and increase the
potential for blood coagulation. Both metabolites influence the out-vascular blood clotting mechanism.
Detected activity manifestations 2-HPSA and β-PESA hemostatic effects may define the hemostasial
effects of the drug with the anti-coagulation properties.

References

Dedov II, Shestakova MV. Saharnyj diabet, Moskva , 2005:209-222.

Dzugkoeva FS, Dzugkoev SG, Hetagurova LG. Fundamental’nye issledovanija 2008; 8:105-106.

Balabolkin MI. Kardiologija 2000; 10:74-87. 4. Arikawa E, Cheung C, Sekirov T, et al. J Physiol Pharmacol 2006; 84(8-9):823-833.

Gorbenko NI. Patogenetychne obg’runtuvannja efektyvnosti pohidnogo jantarnoi’ kysloty — fensukcynalu v terapii’ cukrovogo diabetu ta jogo sudynnyh uskladnen’ (eksperymental’ne doslidzhennja), Harkiv , 2004:36 p.

Palagina IA, Kudria MY, Ustenko NV. Toxicology Letters 2008; 180(1):S241.

Instrukcija po primeneniju nabora dlja jekspressocenki trom-bocitarnogo gemostaza (agreskrin-test), 2010:4 p.

Men’shikov VV. Laboratornye metody issledovanija v klinike: spravochnik, Moskva , 1987:155-157.

Trahtenberg IM, Sova RE, Sheftel’ VO, Onikienko FA. Problema normy v toksikologii (sovremennye predstavlenija i metodicheskie

podhody, osnovnye parametry i konstanty), Moskva , 1998:204 p.

Zubairov DM. Molekuljarnye osnovy svertyvanija krovi i tromboobrazovanija, Kazan’ , 2000:364 p.

Tret’jakova OS. Zdorov’e Ukrainy 2010; 3:51–61.

Romanovskaja VN, Starosel’skaja AN, Zhavoronkov LP. Bjul Jeksperim Biologii i Mediciny 2012; 153(3):286–289.

Shiffman F. Patofiziologija krovi, Moskva , 2000:520 p.

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Published

2013-10-10

How to Cite

Palagina, I. A., & Kudrya, M. Y. (2013). STATE OF THROMBOCYTE-COAGULATION HEMOSTASIS IN RATS UNDER INFLUENCE OF METABOLITES OF SUCCINIC ACID DERIVATIVES. Problems of Endocrine Pathology, 45(3), 82-87. https://doi.org/10.21856/j-PEP.2013.3.11

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