HEPATOPROTECTIVE ACTIVITY OF SPERMATOZOID STIMULATOR — KATIAZYN UNDER CONDITIONS OF EXPERIMENTAL PARACETAMOL-INDUCED LIVER PATHOLOGY

Authors

  • Kudria M. Ya. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Melnikivs’ka N. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Ustenko N. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Pavlenko T. O. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Lalymenko O. S. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Palagina I. A. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Degtyaryova A. L. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Ivashchenko A. D. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2015.4.07

Keywords:

paracetamol-induced hepatitis, katiazin, hepatoprotective properties

Abstract

It was investigated hepatoprotective properties of camphor acid derivative — katiazin under experimental model conditions of paracetamol drug-induced hepatitis. It was proved that katiazin in two doses (10 and 50 mg/kg body weight) stimulates the non-enzymatic antioxidant defense unit, increasing the concentration of the reduced glutathione and sulfhydryl groups. The application of katiazin led to an increase in the prothrombin time, which can be interpreted as a sign of the compound anticoagulant effect. It was found out that the administration of katiazin enhances liver detoxification function, normalizes carbohydrate and lipid metabolism in rats.

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Published

2015-12-03

How to Cite

Kudria, M. Y., Melnikivs’ka, N. V., Ustenko, N. V., Pavlenko, T. O., Lalymenko, O. S., Palagina, I. A., Degtyaryova, A. L., & Ivashchenko, A. D. (2015). HEPATOPROTECTIVE ACTIVITY OF SPERMATOZOID STIMULATOR — KATIAZYN UNDER CONDITIONS OF EXPERIMENTAL PARACETAMOL-INDUCED LIVER PATHOLOGY. Problems of Endocrine Pathology, 54(4), 53-60. https://doi.org/10.21856/j-PEP.2015.4.07

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