OXIDATIVE STRESS AS THE PATHOPHYSIOLOGICAL MECHANISMS IN THE DEVELOPMENT OF DIABETIC MACROANGIOPATHY AND PERSPECTIVES OF ITS CORRECTION BY FLAVONOIDS

Authors

DOI:

https://doi.org/10.21856/j-PEP.2016.3.10

Keywords:

diabetes mellitus, oxidative stress, antioxidant therapy, flavonoids, quercetin

Abstract

The review elucidates the role of oxidative stress in the pathogenesis of diabetic cardiovascularcomplications. It was analyzed the main reasons for excessive production of reactive oxygen speciesin the conditions of hyperglycemia and the basic mechanisms of their damaging effect on the morphological and functional state of the myocardium and endothelium. It was considered theperspective of natural antioxidants, such as flavonoids, for the prevention and treatment of diabeticmacroangiopathy. It was made a retrospective analysis of own researches devoted to the quercetin effect on the main factors of cardiometabolic risk at the insulin resistance syndrome

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Published

2016-08-23

How to Cite

Gorbenko, N., Ivanova, O., & Borikov, O. (2016). OXIDATIVE STRESS AS THE PATHOPHYSIOLOGICAL MECHANISMS IN THE DEVELOPMENT OF DIABETIC MACROANGIOPATHY AND PERSPECTIVES OF ITS CORRECTION BY FLAVONOIDS. Problems of Endocrine Pathology, 57(3), 91-99. https://doi.org/10.21856/j-PEP.2016.3.10

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