MECHANISMS OF THE PATHOGENESIS OF ATHEROSCLEROSIS IN PATIENTS WITH DIABETES. THE ROLE OF NF-КВ (тhe literature review)

Authors

  • Sokolova L. K. SI «V. P. Komissarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine», Kiev, Ukraine
  • Pushkarev V. M. SI «V. P. Komissarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine», Kiev, Ukraine
  • Pushkarev V. V. SI «V. P. Komissarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine», Kiev, Ukraine
  • Tronko M. D. SI «V. P. Komissarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine», Kiev, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2017.2.10

Keywords:

type 2 diabetes, atherosclerosis, nuclear factor NF-κB.

Abstract

The literature review examines the molecular and cellular mechanisms of the pathogenesis of one of
the most serious complications of diabetes — accelerated development of atherosclerosis. Summarized the data
on the major pathways involved in the pathogenesis of this disease on the backgroung of diabetes mellitus:
the formation of superoxide and endothelial dysfunction, the formation of glycated protein products, expression
of their receptors and activating ligands, activation of protein kinase C, increasing the polyol pathway, activa-
tion of hexo samine pathway. Special attention is paid to nuclear factor NF-κB – key regulator of inflammatory
responses in endothelial cells, smooth muscle cells, macrophages, other cell types, which participate on almost
all stages of the atherosclerosis development

References

Siracuse JJ, Chaikof EL. In: G. V. Shrikhande and J. F. McKinsey (eds.), Diabetes and Peripheral Vascular Disease, New-York, 2012: 243 p.

White GE, Iqbal AJ, Greaves DR. Pharmacol Rev 2013; 65(1):47-89.

Zhu P, Sun W, Zhang C, et al. Int J Cardiol 2016; 220:235-241. https://doi.org/10.1016/j.ijcard.2016.06.138

Giacco F, Brownlee M. Circ Res 2010; 107(9):1058-1070. https://doi.org/10.1161/CIRCRESAHA.110.223545

Salvador B, Arranz A, Francisco S, et al. Pharmacol Res 2016; 108:46-56. https://doi.org/10.1016/j.phrs.2016.03.038

Mikhed Y, Daiber A, Steven S. Int J Mol Sci 2015; 16:15918-15953. https://doi.org/10.3390/ijms160715918

Rabelo LA, Ferreira FO, Nunes-Souza V, et al. Oxid Med Cell Longev 2015; 2015:924860.

Yamamoto S, Narita I, Kotani K. Clinica Chimica Acta 2016; 457:117-122. https://doi.org/10.1016/j.cca.2016.04.012

Vanhoutte PM, Zhao Y, Xu A, Leung SWS. Circ Res 2016; 119(2):375-396. https://doi.org/10.1161/CIRCRESAHA.116.306531

Lynch M, Barallobre-Barreiro J, Jahangiri M, Mayr M. J Intern Med 2016; 280:325-338. https://doi.org/10.1111/joim.12486

Bonfeld KE, Tabas I. Cell Metabolism 2011; 14:575-585. https://doi.org/10.1016/j.cmet.2011.07.015

Geraldes P, King GL. Circ Res 2010; 106:1319-1331. https://doi.org/10.1161/CIRCRESAHA.110.217117

Ramasamy R, Goldberg IJ. Circ Res 2010; 106:1449-1458. https://doi.org/10.1161/CIRCRESAHA.109.213447

Kozakova M, Palombo C. Int J Environ Res Public Health 2016; 13(201):1-14.

Younus H, Anwar S. Int J Health Sci (Qassim) 2016; 10(2):261-277.

Vбsquez-Trincado C, Garcнa-Carvajal I, Pennanen C, et al. J Physiol 2016; 594:509-525. https://doi.org/10.1113/JP271301

Yu T, Sheu SS, Robotham JL, Yoon Y. Cardiovasc Res 2008; 79(2):341-351. https://doi.org/10.1093/cvr/cvn104

Saremi A, Howell S, Schwenke DC, et al. Diabetes Care 2017; pii:dc161875. doi: 10.2337/dc16-1875.

Xie Z, Zhang J, Wu J, et al. Diabetes 2008; 57:3222-3230. https://doi.org/10.2337/db08-0610

Yao D, Brownlee M. Diabetes 2010; 59:249-255. https://doi.org/10.2337/db09-0801

Takeuchi M. Diagnostics (Basel) 2016; 6(2). doi:10.3390/diagnostics6020023.

Shah MS, Brownlee M. Circ Res 2016; 118:1808-1829. https://doi.org/10.1161/CIRCRESAHA.116.306923

Erbel C, Achenbach J, Akhavanpoor M, et al. Eur J Med Res 2011; 16(8):367-374. https://doi.org/10.1186/2047-783X-16-8-367

Geraldes P, Hiraoka-Yamamoto J, Matsumoto M, et al. Nat Med 2009; 15:1298-1306. https://doi.org/10.1038/nm.2052

Madonna R, De Caterina R. Vascul Pharmacol 2011; 54(3-6):75-79. https://doi.org/10.1016/j.vph.2011.03.005

Hardivillй S, Hart GW. Cell Metab 2014; 20:208-213. https://doi.org/10.1016/j.cmet.2014.07.014

Bond MR, Hanover JA. J Cell Biol 2015; 208:869-880. https://doi.org/10.1083/jcb.201501101

Shrikhande GV, Scali ST, da Silva CG, et al. PLoS One 2010; 5(12):e14240. https://doi.org/10.1371/journal.pone.0014240

Qian J, Fulton D. Front Physiol 2013; 4:347. https://doi.org/10.3389/fphys.2013.00347

Yan SF, Ramasamy R, Schmidt AM. Circ Res 2010; 106(5):842-853. https://doi.org/10.1161/CIRCRESAHA.109.212217

Queisser MA, Yao D, Geisler S, et al. Diabetes 2010; 59:670-678. https://doi.org/10.2337/db08-1565

Gallagher KA, Liu ZJ, Xiao M, et al. J Clin Invest 2007; 117:1249-1259. https://doi.org/10.1172/JCI29710

Chawla A, Chawla R, Jaggi S. Indian J Endocrinol Metab 2016; 20(4):546-551. https://doi.org/10.4103/2230-8210.183480

Thangarajah H, Yao D, Chang EI, et al. Proc Natl Acad Sci U S A 2009; 106:13505-13510. https://doi.org/10.1073/pnas.0906670106

Soro-Paavonen A, Watson AM, Li J, et al. Diabetes 2008; 57:2461-2469. https://doi.org/10.2337/db07-1808

McLaughlin T, Lamendola C, Liu A, Abbasi F. J Clin Endocrinol Metab 2011; 96(11):E1756-E1760. https://doi.org/10.1210/jc.2011-0615

Thiruvoipati T, Kielhorn CE, Armstrong EJ. World J Diabetes 2015; 6(7):961-969. https://doi.org/10.4239/wjd.v6.i7.961

Muntoni S, Muntoni S. Ann Nutr Metab 2011; 58(1):25-36. https://doi.org/10.1159/000323395

Zhang H, Potter BJ, Cao JM, Zhang C. Basic Res Cardiol 2011; 106(6):1135-1145. https://doi.org/10.1007/s00395-011-0212-x

Du X, Edelstein D, Obici S, et al. J Clin Invest 2006; 116:1071-1080. https://doi.org/10.1172/JCI27030C1

Li S, Brown MS, Goldstein JL. Proc Natl Acad Sci U S A 2010; 107:3441-3446. /doi.org/10.1073/pnas.1009751108

Janus A, Szahidewicz-Krupska E, Mazur G, Doroszko A. Media­tors­Inflamm 2016; 2016:3634948.

Schulman IH, Zhou MS. Curr Hypertens Rep 2009; 11:48-55. https://doi.org/10.1007/s11906-009-0010-0

Tufanli O, Telkoparan Akillilar P, Acosta-Alvear D, et al. Proc Natl Acad Sci U S A 2017; pii:201621188. https://doi.org/10.1073/pnas.1621188114

Brookheart RT, Michel CI, Listenberger LL, et al. J Biol Chem 2009; 284:7446-7454. https://doi.org/10.1074/jbc.M806209200

Ergul A. Pharmacol Res 2011; 63(6):477-482. https://doi.org/10.1016/j.phrs.2011.01.012

Morgantini C, Natali A, Boldrini B, et al. Diabetes 2011; 60(10):2617-2623 . https://doi.org/10.2337/db11-0378

Xiao L, Liu Y, Wang N. Am J Physiol Heart Circ Physiol 2014; 306:H317-H325.https://doi.org/10.1152/ajpheart.00182.2013

Bertoluci MC, Cй GV, da Silva AM, et al. World J Diabetes 2015; 6(5):679-692. https://doi.org/10.4239/wjd.v6.i5.679

Wan A, Rodrigues B. Cardiovasc Res 2016; 111(3):172-183. https://doi.org/10.1093/cvr/cvw159

Grant PJ. J Intern Med 2007; 262(2):157-172. https://doi.org/10.1111/j.1365-2796.2007.01824.x

Capodanno D, Patel A, Dharmashankar K, et al. Circ Cardiovasc Interv 2011; 4(2):180-187. https://doi.org/10.1161/CIRCINTERVENTIONS.110.960187

Avogaro A, Albiero M, Menegazzo L, et al. Diabetes Care 2011; 34(Suppl 2):S285-S290. https://doi.org/10.2337/dc11-1442

Georgescu A, Alexandru N, Constantinescu A, et al. Eur J Pharmacol 2011; 669(1-3):1-6. https://doi.org/10.1016/j.ejphar.2011.07.035

Tian L, Zhang L, Liu J, et al. J Mol Endocrinol 2014; 52(2):215-222. https://doi.org/10.1530/JME-13-0119

Ichiki T. Vascular Pharmacology 2010; 52:151-156. https://doi.org/10.1016/j.vph.2009.09.004

Wang P, Xu TY, Guan YF, et al. Cardiovasc Res 2014; 102(3):448-459. https://doi.org/10.1093/cvr/cvu056

Valentina VN, Marijan B, Chedo D, Branka K. Arq Bras Endocrinol Metabol 2011; 55:475-480. https://doi.org/10.1590/S0004-27302011000700007

Tian L, Ni J, Guo T, et al. Endocrine 2014; 46(3):651-658. https://doi.org/10.1007/s12020-013-0135-4

Pushkarev VM, Kovzun OI, Pushkarev VV, et al. J NAMS Ukr 2015; 21(3-4):287-298.

Pushkarev VM, Sokolova LK, Kovzun OI, et al. Endokrynologia 2016; 21(3):225-238.

Kassan M, Choi S-K, Galбn M, et al. Diabetes 2013; 62(6):2078-2087. https://doi.org/10.2337/db12-1374

Barlovic DP, Soro-Paavonen A, Jandeleit-Dahm KA. Clin Sci (Lond) 2011; 121(2):43-55. https://doi.org/10.1042/CS20100501

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Published

2021-08-18

How to Cite

Sokolova, L. K., Pushkarev, V. M., Pushkarev, V. V., & Tronko, M. D. (2021). MECHANISMS OF THE PATHOGENESIS OF ATHEROSCLEROSIS IN PATIENTS WITH DIABETES. THE ROLE OF NF-КВ (тhe literature review). Problems of Endocrine Pathology, 60(2), 64-76. https://doi.org/10.21856/j-PEP.2017.2.10

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