MECHANISMS OF THE PATHOGENESIS OF ATHEROSCLEROSIS IN PATIENTS WITH DIABETES. THE ROLE OF NF-КВ (тhe literature review)
DOI:
https://doi.org/10.21856/j-PEP.2017.2.10Keywords:
type 2 diabetes, atherosclerosis, nuclear factor NF-κB.Abstract
The literature review examines the molecular and cellular mechanisms of the pathogenesis of one of
the most serious complications of diabetes — accelerated development of atherosclerosis. Summarized the data
on the major pathways involved in the pathogenesis of this disease on the backgroung of diabetes mellitus:
the formation of superoxide and endothelial dysfunction, the formation of glycated protein products, expression
of their receptors and activating ligands, activation of protein kinase C, increasing the polyol pathway, activa-
tion of hexo samine pathway. Special attention is paid to nuclear factor NF-κB – key regulator of inflammatory
responses in endothelial cells, smooth muscle cells, macrophages, other cell types, which participate on almost
all stages of the atherosclerosis development
References
Siracuse JJ, Chaikof EL. In: G. V. Shrikhande and J. F. McKinsey (eds.), Diabetes and Peripheral Vascular Disease, New-York, 2012: 243 p.
White GE, Iqbal AJ, Greaves DR. Pharmacol Rev 2013; 65(1):47-89.
Zhu P, Sun W, Zhang C, et al. Int J Cardiol 2016; 220:235-241. https://doi.org/10.1016/j.ijcard.2016.06.138
Giacco F, Brownlee M. Circ Res 2010; 107(9):1058-1070. https://doi.org/10.1161/CIRCRESAHA.110.223545
Salvador B, Arranz A, Francisco S, et al. Pharmacol Res 2016; 108:46-56. https://doi.org/10.1016/j.phrs.2016.03.038
Mikhed Y, Daiber A, Steven S. Int J Mol Sci 2015; 16:15918-15953. https://doi.org/10.3390/ijms160715918
Rabelo LA, Ferreira FO, Nunes-Souza V, et al. Oxid Med Cell Longev 2015; 2015:924860.
Yamamoto S, Narita I, Kotani K. Clinica Chimica Acta 2016; 457:117-122. https://doi.org/10.1016/j.cca.2016.04.012
Vanhoutte PM, Zhao Y, Xu A, Leung SWS. Circ Res 2016; 119(2):375-396. https://doi.org/10.1161/CIRCRESAHA.116.306531
Lynch M, Barallobre-Barreiro J, Jahangiri M, Mayr M. J Intern Med 2016; 280:325-338. https://doi.org/10.1111/joim.12486
Bonfeld KE, Tabas I. Cell Metabolism 2011; 14:575-585. https://doi.org/10.1016/j.cmet.2011.07.015
Geraldes P, King GL. Circ Res 2010; 106:1319-1331. https://doi.org/10.1161/CIRCRESAHA.110.217117
Ramasamy R, Goldberg IJ. Circ Res 2010; 106:1449-1458. https://doi.org/10.1161/CIRCRESAHA.109.213447
Kozakova M, Palombo C. Int J Environ Res Public Health 2016; 13(201):1-14.
Younus H, Anwar S. Int J Health Sci (Qassim) 2016; 10(2):261-277.
Vбsquez-Trincado C, Garcнa-Carvajal I, Pennanen C, et al. J Physiol 2016; 594:509-525. https://doi.org/10.1113/JP271301
Yu T, Sheu SS, Robotham JL, Yoon Y. Cardiovasc Res 2008; 79(2):341-351. https://doi.org/10.1093/cvr/cvn104
Saremi A, Howell S, Schwenke DC, et al. Diabetes Care 2017; pii:dc161875. doi: 10.2337/dc16-1875.
Xie Z, Zhang J, Wu J, et al. Diabetes 2008; 57:3222-3230. https://doi.org/10.2337/db08-0610
Yao D, Brownlee M. Diabetes 2010; 59:249-255. https://doi.org/10.2337/db09-0801
Takeuchi M. Diagnostics (Basel) 2016; 6(2). doi:10.3390/diagnostics6020023.
Shah MS, Brownlee M. Circ Res 2016; 118:1808-1829. https://doi.org/10.1161/CIRCRESAHA.116.306923
Erbel C, Achenbach J, Akhavanpoor M, et al. Eur J Med Res 2011; 16(8):367-374. https://doi.org/10.1186/2047-783X-16-8-367
Geraldes P, Hiraoka-Yamamoto J, Matsumoto M, et al. Nat Med 2009; 15:1298-1306. https://doi.org/10.1038/nm.2052
Madonna R, De Caterina R. Vascul Pharmacol 2011; 54(3-6):75-79. https://doi.org/10.1016/j.vph.2011.03.005
Hardivillй S, Hart GW. Cell Metab 2014; 20:208-213. https://doi.org/10.1016/j.cmet.2014.07.014
Bond MR, Hanover JA. J Cell Biol 2015; 208:869-880. https://doi.org/10.1083/jcb.201501101
Shrikhande GV, Scali ST, da Silva CG, et al. PLoS One 2010; 5(12):e14240. https://doi.org/10.1371/journal.pone.0014240
Qian J, Fulton D. Front Physiol 2013; 4:347. https://doi.org/10.3389/fphys.2013.00347
Yan SF, Ramasamy R, Schmidt AM. Circ Res 2010; 106(5):842-853. https://doi.org/10.1161/CIRCRESAHA.109.212217
Queisser MA, Yao D, Geisler S, et al. Diabetes 2010; 59:670-678. https://doi.org/10.2337/db08-1565
Gallagher KA, Liu ZJ, Xiao M, et al. J Clin Invest 2007; 117:1249-1259. https://doi.org/10.1172/JCI29710
Chawla A, Chawla R, Jaggi S. Indian J Endocrinol Metab 2016; 20(4):546-551. https://doi.org/10.4103/2230-8210.183480
Thangarajah H, Yao D, Chang EI, et al. Proc Natl Acad Sci U S A 2009; 106:13505-13510. https://doi.org/10.1073/pnas.0906670106
Soro-Paavonen A, Watson AM, Li J, et al. Diabetes 2008; 57:2461-2469. https://doi.org/10.2337/db07-1808
McLaughlin T, Lamendola C, Liu A, Abbasi F. J Clin Endocrinol Metab 2011; 96(11):E1756-E1760. https://doi.org/10.1210/jc.2011-0615
Thiruvoipati T, Kielhorn CE, Armstrong EJ. World J Diabetes 2015; 6(7):961-969. https://doi.org/10.4239/wjd.v6.i7.961
Muntoni S, Muntoni S. Ann Nutr Metab 2011; 58(1):25-36. https://doi.org/10.1159/000323395
Zhang H, Potter BJ, Cao JM, Zhang C. Basic Res Cardiol 2011; 106(6):1135-1145. https://doi.org/10.1007/s00395-011-0212-x
Du X, Edelstein D, Obici S, et al. J Clin Invest 2006; 116:1071-1080. https://doi.org/10.1172/JCI27030C1
Li S, Brown MS, Goldstein JL. Proc Natl Acad Sci U S A 2010; 107:3441-3446. /doi.org/10.1073/pnas.1009751108
Janus A, Szahidewicz-Krupska E, Mazur G, Doroszko A. MediatorsInflamm 2016; 2016:3634948.
Schulman IH, Zhou MS. Curr Hypertens Rep 2009; 11:48-55. https://doi.org/10.1007/s11906-009-0010-0
Tufanli O, Telkoparan Akillilar P, Acosta-Alvear D, et al. Proc Natl Acad Sci U S A 2017; pii:201621188. https://doi.org/10.1073/pnas.1621188114
Brookheart RT, Michel CI, Listenberger LL, et al. J Biol Chem 2009; 284:7446-7454. https://doi.org/10.1074/jbc.M806209200
Ergul A. Pharmacol Res 2011; 63(6):477-482. https://doi.org/10.1016/j.phrs.2011.01.012
Morgantini C, Natali A, Boldrini B, et al. Diabetes 2011; 60(10):2617-2623 . https://doi.org/10.2337/db11-0378
Xiao L, Liu Y, Wang N. Am J Physiol Heart Circ Physiol 2014; 306:H317-H325.https://doi.org/10.1152/ajpheart.00182.2013
Bertoluci MC, Cй GV, da Silva AM, et al. World J Diabetes 2015; 6(5):679-692. https://doi.org/10.4239/wjd.v6.i5.679
Wan A, Rodrigues B. Cardiovasc Res 2016; 111(3):172-183. https://doi.org/10.1093/cvr/cvw159
Grant PJ. J Intern Med 2007; 262(2):157-172. https://doi.org/10.1111/j.1365-2796.2007.01824.x
Capodanno D, Patel A, Dharmashankar K, et al. Circ Cardiovasc Interv 2011; 4(2):180-187. https://doi.org/10.1161/CIRCINTERVENTIONS.110.960187
Avogaro A, Albiero M, Menegazzo L, et al. Diabetes Care 2011; 34(Suppl 2):S285-S290. https://doi.org/10.2337/dc11-1442
Georgescu A, Alexandru N, Constantinescu A, et al. Eur J Pharmacol 2011; 669(1-3):1-6. https://doi.org/10.1016/j.ejphar.2011.07.035
Tian L, Zhang L, Liu J, et al. J Mol Endocrinol 2014; 52(2):215-222. https://doi.org/10.1530/JME-13-0119
Ichiki T. Vascular Pharmacology 2010; 52:151-156. https://doi.org/10.1016/j.vph.2009.09.004
Wang P, Xu TY, Guan YF, et al. Cardiovasc Res 2014; 102(3):448-459. https://doi.org/10.1093/cvr/cvu056
Valentina VN, Marijan B, Chedo D, Branka K. Arq Bras Endocrinol Metabol 2011; 55:475-480. https://doi.org/10.1590/S0004-27302011000700007
Tian L, Ni J, Guo T, et al. Endocrine 2014; 46(3):651-658. https://doi.org/10.1007/s12020-013-0135-4
Pushkarev VM, Kovzun OI, Pushkarev VV, et al. J NAMS Ukr 2015; 21(3-4):287-298.
Pushkarev VM, Sokolova LK, Kovzun OI, et al. Endokrynologia 2016; 21(3):225-238.
Kassan M, Choi S-K, Galбn M, et al. Diabetes 2013; 62(6):2078-2087. https://doi.org/10.2337/db12-1374
Barlovic DP, Soro-Paavonen A, Jandeleit-Dahm KA. Clin Sci (Lond) 2011; 121(2):43-55. https://doi.org/10.1042/CS20100501