RET/PTC1/3 AND BRAF W T/MUT mRNA E XPRESSION IN TUMORS OF THE HUMAN THYROID
DOI:
https://doi.org/10.21856/j-PEP.2017.2.05Keywords:
: human thyroid, highly differentiated malignant tumors, rearrangements RET/PTC, mutations and expression of BRAF.Abstract
There were studied the chromosomal translocation of receptor tyrosine kinase gene RET/PTC1, RET/PTC3,
gene mutations of protein kinase B-RAF (BRAFV600E) and the expression of BRAFwt in the multinodular
goiter tissue, follicular and papillary carcinoma of the human thyroid. Of the 29 tissue samples which were
studied, changes in the expression, gene mutations and rearrangements were detected in 11 cases (38 %). In one
tumor sample of papillary carcinoma double rearrangement of the gene RET — RET/PTC1 and RET/PTC3 was
found. In a more aggressive invasive tumors the expression level RET/PTC1 and RET/PTC3 was higher than
in encapsulated tumors. It was observed the increased expression of protein kinase BRAF (BRAFwt) in some
samples of tumor tissue of follicular carcinoma and multinodular goiter.
The significance of MAPK signaling pathway in tumors of the thyroid was discussed.
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