Peculiarities of changes in hormonal and biochemical parameters in patients with pcos and autoimmune thyroid disease

Authors

  • Arkhypkina T. L. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Goncharova О. А. Kharkiv Medical Academy of Postgraduate Education Ukraine
  • Lyubimovа L. P. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Misiura K. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Tyashelova O. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2018.1.01

Keywords:

polycystic ovary syndrome, autoimmune thyroid disease, subclinical hypothyroidism

Abstract

It was examined 55 patients with PCOS that were divided into groups depending on the functional state of the thyroid gland: 21 women with autoimmune thyroiditis in euthyroid stage, 14 women with autoimmune thyroiditis which was combined with subclinical hypothyroidism, 20 — without a thyroid dysfunction. It was found that the euthyroid dysfunction aggravates the typical for the classic phenotype of PCOS the hormonal disorders — increase the total testosterone, the free androgen index and decrease the sex-steroid-binding globu­lin. The absence of a correlation between TTG and LH, LG / FSH indicates different mechanisms formation of PCOS and thyroid pathology.

References

Podzolkova NM. Koloda JuA. Farmateka 2016; 3: 8-15.

Mueller A, Schöfl C, Dittrich R, et al. Hum Reprod 2009;24(11): 2924-2930. doi: http://doi.org/10.1093/humrep/dep285.

Al Sayed A, Al Ali N, Bo Abbas Y, Alfadhli E. Endocrine J 2006;53(5): 653-657. doi: http://doi.org/10.1507/endocrj.k06-018.

Valkenburg O, Steegers-Theunissen RPM, Smedts HPM,et al. J Clin Endocrinol Metabol 2008; 93(2): 470-476.doi: http://doi.org/10.1210/jc.2007-1756.

Tuzcu A, Bahceci M, Gokalp D, et al. Endocrine J 2005;52(1): 89-94. doi: http://doi.org/10.1507/endocrj.52.89.

Fröhlich E, Wahl R. Front Immunol 2017; 8: 521. doi: http://doi.org/10.3389/fimmu.2017.00521.

Calvar CE, Bengolea SV, Deutsch SI, et al. Medicina (B Aires) 2015; 75(4): 213-217.

Gaberšček S, Zaletel K, Schwetz V, et al. Eur J Endocrinol 2015; 172(1): R9-21. doi: http://doi.org/10.1530/EJE-14-0295.

Canellada A, Alvarez I, Berod L, et al. J Steroid Biochem Mol Biol 2008; 111(3-5): 255-261. doi: http://doi.org/10.1016/j.jsbmb.2008.06.009.

Petríková J, Lazúrová I, Yehuda S. Eur J Intern Med 2010; 21(5): 369-371. doi: http://doi.org/10.1016/j.ejim.2010.06.008.

Oravec S, Hlavacka S. Ceska Gynecol 2000; 65(1): 53-57.

Pavonen T. Ann Med 1994; 26(4): 255-258. doi: http://doi.org/10.3109/0785389940914790020.

Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Fertil Steril 2004; 81(1): 19-25.

Podzolkova NM, Koloda JuA. Farmateka 2017; 3(35):84-88.

Kachuei M, Jafari F, Kachuei A, Keshteli A. Arch Gynecol Obstet 2012; 285(3): 853-856. doi: http://doi.org/10.1007/s00404-011-2040-5.

Petrikova J, Lazurova I, Dravecka I, et al. Biomedical Papers of the Medical Faculty of Palacký University, Olomouc, Czech Republic 2015; 159(2): 302-306. doi: http://doi.org/10.5507/bp.2014.062.

Poppe K, Velkeniers B, Glinoer D. Clin Endocrinol (Oxf) 2007; 66: 309-321.

Ivanova GI, Gorobec LN. Zhurnal nevrologii i psihiatrii im. SS. Korsakova 2010;110(1): 33-41.

Pan’kiv VI. Medychni aspekty zdorov’ja zhinky 2011;7(47): 62-65.

Manuhin I.B., Gevorkian M.A., Chagai N.B. Anovulation and insulin resistance. GEOTAR-Media, 2006. 416 p.

Enzevaei A, Salehpour S, Tohidi M, Saharkhiz N. Iranian J Reprod Med 2014; 12(7): 481-486.

Karaköse M, Hepsen S, Çakal E, et al. J Turk Ger Gynecol Assoc 2017; 18(2): 85-89. doi: http://doi.org/10.4274/jtgga.2016.0217.

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Published

2021-06-30

How to Cite

Arkhypkina, T. L. ., Goncharova О. А. ., Lyubimovа L. P. ., Misiura, K. V. ., & Tyashelova, O. V. . (2021). Peculiarities of changes in hormonal and biochemical parameters in patients with pcos and autoimmune thyroid disease. Problems of Endocrine Pathology, 63(1), 7-15. https://doi.org/10.21856/j-PEP.2018.1.01

Issue

Section

CLINICAL ENDOCRINOLOGY