RISK FACTORS CARDIOVASCULAR AUTONOMIC NEUROPATHY IN TYPE 1 DIABETES MELLITUS
DOI:
https://doi.org/10.21856/j-PEP.2019.2.09Keywords:
diabetes mellitus type 1, cardiac autonomic neuropathy, cardiovascular reflex tests, heart rate variabilityAbstract
Cardiac autonomic neuropathy (CAN) is frequent, life-threatening complications of diabetes mellitus (DM), increasing the mortality and cardiovascular morbidity in diabetes mellitus patients.
The article describes the prevalence, relationship and risk factors of CAN in patients with type 1 diabetes mellitus. We included 23 patients with type 1 diabetes and 17 healthy patients. Using the cardiovascular reflex Ewing tests, which are the «golden» standard for the diagnosis of CAN, we investigated the time-domain and spectral parameters of heart rate variability (HRV). Patients with type 1 diabetes had a statistically significant decrease in the parameters of time-domain and spectral analysis of HRV and high LF/HF ratio during spectral analysis, indicating an increase in the tone of the sympathetic autonomic nervous system and a decrease in the autonomic parasympathetic department nervous system. Using linear regression analysis, it was revealed that the age of patients plays a role in the development of CAN in patients with type 1 diabetes and the glycosylated hemoglobin was correlated only with the sympathetic-parasympathetic coefficient. We did not find the relationship of the CAN with distal symmetrical polyneuropathy, retinopathy and diabetic kidney disease.
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