SINGLE NUCLEOTIDE POLYMORPHISM –11391 G>A OF ADIPONECTIN GENE (ADIPOQ) IN TYPE 2 DIABETES PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
DOI:
https://doi.org/10.21856/j-PEP.2014.3.01Keywords:
type 2 diabetes, non-alcoholic fatty liver disease, adiponectin gene, a single nucleotide polymorphismAbstract
It was studied the single nucleotide polymorphism (SNP) in the promoter region of –11391 G > A adiponectin gene (ADIPOQ) in patients with type 2 diabetes (n = 223) and healthy inhabitants of Kharkiv (n = 51). It was established the absence of significant differences in allele frequency for SNP –11391 G > A in patients with type 2 diabetes (pG = 0.856 pA = 0.144 ), diabetes mellitus patients complicated with non-alcoholic fatty liver disease (pG = 0.850 pA = 0.150 ) and healthy individuals (pG = 0.911 pA = 0.088 ). According to the results of the study the contribution of genetic components in the propensity formation for the development of non-alcoholic fatty liver disease in patients with diabetes in SNP –11391 G > A gene ADIPOQ was not identified. The data obtained have proved promising of further research, which should be based on a study of the role of other candidate genes in the development of non-alcoholic fatty liver disease and their relationship with various metabolic parameters which may allow clarifying the role of genes in disease formation
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