APOPTOSIS OF PANCREATIC BETA-CELLS AS A NEW TARGET FOR INSULIN THERAPY OF PATIENTS WITH TYPE 1 AND 2 DIABETES MELLITUS
DOI:
https://doi.org/10.21856/j-PEP.2015.1.12Keywords:
apoptosis, pancreatic beta-cells, diabetes mellitus, insulin analoguesAbstract
There is a review of the mechanisms of pancreatic beta-cell programmed death (apoptosis) in type 1 and 2 diabetes mellitus. Based on the evidence of anti-apoptotic physiological effects of insulin the necessity of new therapeutic strategy focused on maximal beta-cell function and mass preserving in diabetic patients using modern effective insulin therapy regimen is ground. The advantages of the both long- and short-acting insulin analogues (Lantus® and Apidra®) for early aggressive and safe glucose lowering therapy warranted to beta-cell preservation are argued.
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