FEATURES OF CHANGES IN CIRCADIAN RHYTHM OF CIRCULATING LEVELS OF INSULIN AND GLUCOSE IN THE METABOLIC SYNDROME INDUCED EXPERIMENTAL HYPOPINEALISM

Authors

  • Mishchenko T. V. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Gladkih A. I. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Poltorak V. V. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Bondarenko L. O. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2015.1.10

Keywords:

hypopinealism, metabolic syndrome, insulin, glucose, daily rhythm

Abstract

In the experimental study on young adult male rabbits it was found leveling of circadian rhythm in insulin concentration and violation of circadian pattern of glucose (inversion, which is replaced by leveling) in the dynamics of the formation of metabolic syndrome, which develops in the hypopinealism induced by long-term exposure to low-light in the dark. Change in the circadian rhythm of secretion of insulin, glucose, and hyperinsulinemia that result of chronic disturbance of natural light/dark cycle, are the basis of the manifestation of the metabolic syndrome in hypopinealism.

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Published

2021-06-23

How to Cite

Mishchenko, T. V., Gladkih, A. I., Poltorak, V. V., & Bondarenko, L. O. (2021). FEATURES OF CHANGES IN CIRCADIAN RHYTHM OF CIRCULATING LEVELS OF INSULIN AND GLUCOSE IN THE METABOLIC SYNDROME INDUCED EXPERIMENTAL HYPOPINEALISM. Problems of Endocrine Pathology, 51(1), 73-79. https://doi.org/10.21856/j-PEP.2015.1.10

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