CARBOHYDRATE EXCHANGE IMPACT ON EXTRACELLULAR MATRIX IN PATIENTS WITH ACUTE MYOCARIAL INFARCTION AND TYPE 2 DIABETES MELLITUS

Authors

  • Koteliukh M. Yu. Kharkiv National Medical University, department of internal medicine № 2 and clinical immunology and allergology, Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2016.1.04

Keywords:

hyperglycemia, acute myocardial infarction, tenascin C, extracellular matrix, type 2 diabetes mellitus.

Abstract

The study involved examination of 60 patients with acute myocardial infarction and type 2 diabetes mellitus, 40 patients with acute myocardial infarction and without type 2 diabetes mellitus and 20 substantially healthy subjects. The research allowed the authors to evaluate the effect of carbohydrate metabolism on extracellular matrix components in patients with acute myocardial infarction with the presence or absence of type 2 diabetes mellitus. The correlation relationship in patients with acute myocardial infarction and type 2 diabetes mellitus was found to be as follows: between matrix metalloproteinase-13 on the 1st–2nd day and glucose (r = 0.36; p < 0.05), glycosylated hemoglobin (r = 0.42; p < 0.05); tissue inhibitor of metalloproteinase-4 and glucose (r = 0.22; p < 0.05); tenascin C and glycosylated hemoglobin (r = –0.28; p < 0.05), glucose (r = –0.24; p < 0.05).

References

Shindler DM, et al. J Am Coll Cardiol 2000;36(3):1097-1103.

Malmberg K, et al. Circulation 2000; 102:1014-1019.

Drapkina OM, Gegenava BB. Jendokrinologija: novosti, mnenija, obuchenie 2015; 3:84-92.

Drapkina OM, Gegenava BB. Racional’naja Farmakoterapija v Kardiologii 2013; 9(1):62-65.

Lupach NM, et al. Tihookeanskij Med Zhurn 2010;4:71-74.

Midwood S. Kim, et al. Cell Mol Life Sci 2011;68:3175-3199.

Vanhoutte D, et al. Cardiovasc Res 2006; 69:604-613.

Gruzdeva OV, et al. Citokiny i Vospalenie 2012;11(2):44-50.

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Published

2021-08-18

How to Cite

Koteliukh, M. Y. . (2021). CARBOHYDRATE EXCHANGE IMPACT ON EXTRACELLULAR MATRIX IN PATIENTS WITH ACUTE MYOCARIAL INFARCTION AND TYPE 2 DIABETES MELLITUS. Problems of Endocrine Pathology, 55(1), 29-35. https://doi.org/10.21856/j-PEP.2016.1.04

Issue

Section

CLINICAL ENDOCRINOLOGY