THE IMPACT OF SELECTIVE ESTROGEN RECEPTOR MODUL ATOR PE0607 ON MITOCHONDRIA FUNCTIONAL STATE IN HE ART OF OVARIECTOMIZED RATS WITH TYPE 2 DIABETES

Authors

DOI:

https://doi.org/10.21856/j-PEP.2017.2.09

Keywords:

: type 2 diabetes, estrogen deficiency, mitochondrial dysfunction, selective estrogen receptor modulator

Abstract

The impact of selective estrogen receptor modulator PE0607 on mitochondrial dysfunction in heart of ovariectomized rats with type 2 diabetes was investigated. It was established that oral administration of PE0607 decreases production of reactive oxygen species (hydrogen peroxide) in cardiomyocyte mitochondria and increases
aconitase activity and cytochromes с, с1, b, аа3
concentration by control rate in heart of diabetic rats with hypoestrogenia. These results justify the PE0607 availability as a gender-specific agent to impair cardiovascular
risk in diabetic women with estrogen deficiency.

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Published

2017-05-23

How to Cite

Kiprich, T. (2017). THE IMPACT OF SELECTIVE ESTROGEN RECEPTOR MODUL ATOR PE0607 ON MITOCHONDRIA FUNCTIONAL STATE IN HE ART OF OVARIECTOMIZED RATS WITH TYPE 2 DIABETES. Problems of Endocrine Pathology, 60(2), 57-63. https://doi.org/10.21856/j-PEP.2017.2.09