Adipokine`s profile effects on the metabolic disorders and cardiac remodeling in patients with arterial hypertension and type 2 diabetes

Authors

  • Bilovol O. N. Kharkiv National Medical University, Kharkiv, Ukraine
  • Bobronnikova L. R. Kharkiv National Medical University, Kharkiv, Ukraine
  • Al-Trawneh O. V. Kharkiv National Medical University, Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2017.3.02

Keywords:

hypertension, type 2 diabetes, visfatin, omentin, myocardial remodeling

Abstract

The aim of the work was to study the effect of apelin and omentin`s activity on the progression of metabolic disorders and myocardial remodeling in patients with hypertension (AH) and type 2 diabetes (DM2). The study involved 44 patients with stage II and 2 degrees of AH, combined with DM2 type 2 and 42 patients with stage II and 2 degrees of hypertension without DM2. The control group consisted of 20 practically healthy persons. It has been found that during the combined course of AH and DM2 was observed hypervisfatinemiya and hypoomentinemiya that is significantly correlated with the development and progression of the atherogenic dyslipidemia, carbohydrate disorders, insulin resistance and myocardial remodeling, that greatly increases the cardiovascular risk in the patients.

References

Arror AR. Heart Fail Clin 2012; 8(4):3133-3140.

Ruden I, Standi E, Barnic M, et al. Eur Heart J 2012; 28(1):88-136.

Schillaci G, Verdecchia P, Porcellati C. Hypertension 2009; 35:580-586.

Vakili BA, Okin PM, Devereux RB. Am Heart J 2009; 141:334-341.

Koguchi W, Kobayashi N, Takeshima H, et al. Circ J 2012; 76(1):137-144.

Ouchi N, Ohashi K, Shibata R, Murohara T. Circ J 2016; 80:2073-2080.

Chang YH, Chang DM, Lin KC, et al. Diabetes Metab Res Rev 2011; 27:515-527.

Chang Y, Chang T, Lee W, Chuang L. Metab Clin Exp 2010; 59(1):93-99.

Uslu S, Kara M. Exp Ther Med 2012; 4(1):113–120. https://doi.org/10.3892/etm.2012.557.

Brown JE, Onyango DJ, Ramanjaneya M, et al. J Mol Endocrinol 2010; 44(3):171-178.

Gunes F, Akbal E, Cakir E, et al. Intern Med 2012; 51(6):553-557.

Panagiotou G, Mu L, Na B, et al. Metabolism 2014; 63(10):1265-1271.

Carstensen-Kirberg M, Biemann R, di Giuseppe R, et al. Diabetes Care 2016; 39(6):79-80.

Yamawaki H, Tsubaki N, Mukohda M, et al. Biochem Biophys Res Commun 2010; 19:668-672.

Al-Kuraishy HM, Hamada MT, Al-Samerraie AY. Mustansiriya Med J 2016; 15(1):49-55.

Ling-Zhi Dou, Xiao-Qing Wang. Asian Pacific J Tropical Med 2014; 7(1):55-62.

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Published

2021-06-24

How to Cite

Bilovol, O. N., Bobronnikova, L. R., & Al-Trawneh, O. V. (2021). Adipokine`s profile effects on the metabolic disorders and cardiac remodeling in patients with arterial hypertension and type 2 diabetes. Problems of Endocrine Pathology, 61(3), 17-23. https://doi.org/10.21856/j-PEP.2017.3.02

Issue

Section

CLINICAL ENDOCRINOLOGY