STREPTOZOTOCIN-INDUCED TYPE 1 DIABETES MELLITUS: FORMATION MECHANISMS AND PRACTICAL ASPECTS OF EXPERIMENTAL MODELING (literature review)*
DOI:
https://doi.org/10.21856/j-PEP.2018.2.08Keywords:
streptozotocin, type 1 diabetes mellitus, animal modelAbstract
In the review the present-day views about mechanisms of streptozotocin-induced type 1 diabetes mellitus
development and methodical recommendations for its experimental modeling are presented. The mechanisms of
streptozotocin-induced insulin-dependent diabetes mellitus development have been considered according to four
ways of the diabetogen influence on β-cells:
1) DNA alkylating;
2) donating NO/NO expression intensification;
3) oxidative stress development;
4) lowering N-acetyl-β-D-glucosaminidase activity.
Methodical recommendations for streptozotocin-induced type 1 diabetes mellitus experimental modeling
are presented by the criteria:
1) animal species, breed, line;
2) animal gender;
3) animal age;
4) number of streptozotocin administrations;
5) recommended streptozotocin dose;
6) streptozotocin solution preparation;
7) routs of streptozotocin administration;
8) streptozotocin-induced type 1 diabetes mellitus correction.
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