TY - JOUR AU - Karlovich, N. V. AU - Spiridonova, O. AU - Sazonava, A. G. AU - Valovik, O. E. AU - Ilynchik, O. V. AU - Volchek, Y. A. AU - Mokhort, T. V. PY - 2020/05/20 Y2 - 2024/03/28 TI - SECONDARY HYPERPARATHYROIDISM AND BONE METABOLISM IN PATIENTS WITH END-STAGE OF CHRONIC KIDNEY DISEASE JF - Problems of Endocrine Pathology JA - PEP VL - 72 IS - 2 SE - DO - 10.21856/j-PEP.2020.2.04 UR - https://www.jpep.endocrinology.org.ua/index.php/1/article/view/87 SP - 34-43 AB - <p>190 patients with end-stage of chronic kidney disease were clustered using a neural network algorithm to<br>isolate the group with the most optimal PTH and bone metabolism, followed by analysis in each group of laboratory parameters and patient survival. It was found that at a PTH level of 114-490 pg / ml, optimal indicators of<br>bone mineral density and metabolism, and better survival rates of dialysis patients are noted. Both a decrease<br>and an increase in PTH can lead to a critical imbalance in bone metabolism and an adverse outcome, including<br>loss of BMD and shortened life expectancy. In addition to the level of PTH, an adaptive increase in osteocalcin<br>and CTx, and an age-associated decrease in BMD are important in determining the prognosis of bone tissue<br>and patient survival. These factors must be taken into account when diagnosing secondary hyperparathyroidism and determining the tactics of its treatment and observation</p> ER -