TY - JOUR AU - Borikov, Oleksii PY - 2010/12/28 Y2 - 2024/03/29 TI - THE PROTECTIVE EFFECT OF QUERCETIN ON THE DEVELOPMENT OF METABOLIC SYNDROME IN THE OVARIECTOMIZED RATS FED WITH THE HIGH-FAT DIET JF - Problems of Endocrine Pathology JA - PEP VL - 34 IS - 4 SE - DO - 10.21856/j-PEP.2010.4.12 UR - https://www.jpep.endocrinology.org.ua/index.php/1/article/view/867 SP - 85-93 AB - <p>The aim of the study was to investigate the impact of quercetin on the metabolic manifestations&nbsp;of insulin resistance syndrome induced by high-fat diet in rats under estrogen deficiency. It was&nbsp;revealed that treatment with quercetin ameliorated insulin resistance, decreased visceral fat mass&nbsp;and lipid peroxidation in serum and heart, increased endogen nitric oxide production and decreased&nbsp;ADP-induced platelet aggregation in the ovariectomized rats fed with the high-fat diet. These results&nbsp;show that the quercetin may be used for treatment of the cardio-vascular diseases in postmenopausal<br>women.</p> ER -