TY - JOUR AU - Trzhetsinskiy, S. D. PY - 2010/12/28 Y2 - 2024/03/28 TI - THE INFLUENCE OF OXYTOCIN ON PRO- AND ANTIOXIDANT STATE AT DIABETIC ANIMALS JF - Problems of Endocrine Pathology JA - PEP VL - 34 IS - 4 SE - DO - 10.21856/j-PEP.2010.4.08 UR - https://www.jpep.endocrinology.org.ua/index.php/1/article/view/852 SP - 54-60 AB - <p>The aim of the investigation was to study the influence of course central and peripheral oxytocin<br>introduction on the state of pro- and antioxidant systems in healthy and diabetic animals. It is<br>found out that oxytocin introduction promotes the decrease of the activity of free radical oxidation&nbsp;process in erythrocytes in healthy animals. In diabetic animals, which were administered oxytocin&nbsp;by, the significant decrease of the content of primary, secondary and definitive products of peroxide&nbsp;lipid acidification has been observed. It has been registered on the background of the increase of&nbsp;catalase and glutationreductase activities and the increase of α-tocopherol content. These changes of&nbsp;antioxidant components activity of erythrocytes defense were actually higher in the process of central&nbsp;introduction of neuropeptide. The results observed show the antioxidant activity of oxytocin that&nbsp;may be realized through the intensification of antioxidant defense processes</p> ER -