TY - JOUR AU - Shlyakhova, N. V. AU - Budreyko, E. A. AU - Chumak, S. A. PY - 2012/03/15 Y2 - 2024/03/29 TI - VASCULAR ENDOTHELIAL GROWTH FACTOR AS MARKER OF VASCULAR DYSFUNCTIONS IN OBESITY CHILDREN JF - Problems of Endocrine Pathology JA - PEP VL - 39 IS - 1 SE - DO - 10.21856/j-PEP.2012.1.03 UR - https://www.jpep.endocrinology.org.ua/index.php/1/article/view/671 SP - 26-32 AB - <p>In the study was analyzed the serum level of vascular endothelial growth factor (VEGF) at 87 obesity children 9–17 years old of both sex. Significant increase of serum concentration VEGF at obesity children in comparison with healthy controls was established, especially at presence hyperinsulinemia, insulin resistance and microvasculature dysfunction, in less — at the arterial hypertension and microalbuminuria. The role of VEGF as indicator of formation of vascular dysfunctions at obesity children and adolescents on the basis of the revealed associations of its increased levels (more than 320 pg/ml and, especially, more than 450 pg/ml) with hyperinsulinemia, insulin resistance and microvasculature dysfunction was discussed.</p> ER -