TY - JOUR AU - Gorshunska, Maryana AU - Karachentsev, Yuri AU - Kravchun, Nona AU - Atramentova, L. A. AU - Gladkih, A. I. AU - Krasova, Nataliya AU - Leshchenko, Zhanna AU - Tyzhnenko, T. V. AU - Opaleiko, Yu. A. AU - Pochernyayev, A. K. AU - Poltorak, V. V. PY - 2013/06/18 Y2 - 2024/03/29 TI - SINGLE NUCLEOTIDE POLYMORPHISM OF ADIPONECTIN GENE (+276G > T) AND EXPRESSION OF INSULIN-RESISTANT STATE COMPONENTS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS JF - Problems of Endocrine Pathology JA - PEP VL - 44 IS - 2 SE - DO - 10.21856/j-PEP.2013.2.01 UR - https://www.jpep.endocrinology.org.ua/index.php/1/article/view/551 SP - 7-17 AB - <p>Single nucleotide polymorphism +276G &gt; T of adiponectin gene (ADIPOQ) in type 2 diabetes<br>mellitus patients (n=544) and healthy habitants (n = 215) of Kharkiv was studied. There were<br>no significant differences of single nucleotide polymorphism +276 G &gt; T frequencies for patients<br>(pG = 0.691; pT = 0,309) and healthy subjects (pG = 0,601; pT = 0,399). However diabetic patients had<br>increased percentage of homozygote TT and decreased percentage of homozygote GG. Homozygosity<br>in the minor allele T enhances significantly risk of disease in general population (OR 1,98; 95 %<br>CI 1,14–3.32, p &lt; 0.05) and homozygosity in the major allele G creates protective effect (OR 0,66; 95 %<br>CI 0,48–0.90, p &lt; 0.05). Functional meaning of single nucleotide polymorphism in the locus +276G &gt; T<br>of ADIPOQ gene for hypoadiponectinemia genesis was verified as complementary to determining<br>impact of diabetic endophenotype (hyperinsulinemia, insulin resistance, gluco- and lipotoxicity, central<br>type of fat distribution).</p> ER -