TY - JOUR AU - Khaziev, V. V. PY - 2013/10/10 Y2 - 2024/03/29 TI - FEATURES OF CELLULAR COMPOSITION OF LYMPHO-MACROPHAGE INFILTRATION IN THE STROMA OF BENIGN AND MALIGNANT NODAL THYROID NEOPLASMS JF - Problems of Endocrine Pathology JA - PEP VL - 45 IS - 3 SE - DO - 10.21856/j-PEP.2013.3.02 UR - https://www.jpep.endocrinology.org.ua/index.php/1/article/view/508 SP - 14-21 AB - <p>It was conducted immunohistochemical definition of the relative amounts of CD8 (T-lymphocytes<br>suppressor), CD4 (T-lymphocyte helper/inducer), CD3 (total population of T-lymphocytes), CD22<br>(B-lymphocytes), CD16 (macrophages and natural killer) and interleukin-2-producing cells (IL-2) in<br>the preparations of euthyroid nodular thyroid disease: single and multinodal colloid goiter, thyroid<br>follicular adenomas (norm-follicular, macrofollicular, microfollicular, trabecular and solid), thyroid<br>cancer (follicular, papillary, medullary). The nodular goiter characterized by a low level of T-killer,<br>IL-2 and CD3 lymphocytes compared with follicular adenoma and thyroid cancer. Follicular adenoma<br>characterized by a high number of IL-2 and a low ratio T-killer/IL-2. In the samples of thyroid cancer<br>revealed a high level of lymphocyte with CD3 phenotype and T-killer cells as well as the ratio of<br>CD4/CD8; CD22, CD4, CD8 were minor, that indicated on the expressed cellular immunosuppression<br>in thyroid cancer infiltrates.</p> ER -