TY - JOUR AU - Urbanovych, A. M. PY - 2021/06/24 Y2 - 2024/03/29 TI - THE IMPACT OF TREATMENT WITH GLIMEPIRIDE CONTENT OF CERTAIN ADIPOSE TISSUE HORMONES AND CYTOKINES IN PATIENTS WITH NEWLY DIAGNOSED TYPE 2 DIABETES JF - Problems of Endocrine Pathology JA - PEP VL - 58 IS - 4 SE - DO - 10.21856/j-PEP.2016.4.05 UR - https://www.jpep.endocrinology.org.ua/index.php/1/article/view/400 SP - 36-41 AB - <p>The aim of the research was to study the effect of the drug glimepiride on adipose tissue hormones levels (leptin, resistin) and cytokines (IL-2, IL-6, TNF-α) in type 2 diabetes. 28 patients with newly diagnosed type 2 diabetes were examined before and after 12 months of hypoglycemic glimepiride monotherapy. The results indicate that the normalization of carbohydrate metabolism, cytokines levels after the treatment is caused not only by the direct influence of glimepiride in β-cells of the pancreas, but also by its ability to modulate the secretion of proinflammatory cytokines.</p> ER -