TY - JOUR AU - Kiprich, Tetiana AU - Gorbenko, Nataliia AU - Borikov, Oleksii AU - Ivanova, Olha PY - 2016/03/02 Y2 - 2024/03/28 TI - THE IMPACT OF ENDOGENOUS AND EXOGENOUS ESTROGENS ON METABOLIC DISTURBANCES IN FEMALE RATS WITH TYPE 2 DIABETES JF - Problems of Endocrine Pathology JA - PEP VL - 55 IS - 1 SE - DO - 10.21856/j-PEP.2016.1.06 UR - https://www.jpep.endocrinology.org.ua/index.php/1/article/view/351 SP - 41-47 AB - <p>It was investigated the impact of endogenous and exogenous estrogens on metabolic disturbances in female rats with type 2 diabetes. It was established that hypoestrogenic state increases insulin resistance, but doesn’t affect basal hyperglycemia, dyslipidemia and visceral obesity in diabetic female rats. Administration of compound PE0607 with selective estrogen-like activity as well as 17β-estradiol doesn’t influence hyperglycemia and insulin sensitivity, but suppresses dyslipidemia development. These results justify the perspectives of compound PE0607 use as a potential gender-specific agent for attenuation of cardiometabolic risk in type 2 diabetic women.</p> ER -