TY - JOUR AU - Konovchuk, V. M. AU - Andrushchak, A. V. AU - Kushnir, S. V. AU - Kokalko, M. M. AU - Moroz, P. V. PY - 2020/08/31 Y2 - 2024/03/29 TI - SPECIFIC CHARACTERISTICS OF XYLATE ACTION UNDER CONDITIONS OF ANGIOTENSIN-CONVERTING ENZYME INHIBITOR USE ON THE VOLUME- AND OSMOREGULATORY FUNCTION OF THE KIDNEYS IN PATIENTS WITH DIABETES MELLITUS TYPE 2 COMPLICATED BY ENDOGENOUS INTOXICATION SYNDROME JF - Problems of Endocrine Pathology JA - PEP VL - 73 IS - 3 SE - DO - 10.21856/j-PEP.2020.3.04 UR - https://www.jpep.endocrinology.org.ua/index.php/1/article/view/28 SP - 33-39 AB - <p>Introduction. Clinical course of diabetes mellitus is often adhered by purulent-septic pathology, and endogenous<br>intoxication syndrome (DMSEI) develops. Disorders of the compensatory mechanisms of homeostasis<br>providing — volume- and osmoregulatory function of the kidneys arise. Preparations of five-atomic alcohol<br>(xylate) and angiotensin-converting enzyme inhibitor (ACEI, lizinopril) meet the correction requirements.<br>The purpose of the work. To investigate the effect of xylate in combination with angiotensin — converting<br>enzyme inhibitor on the volume- and osmoregulatory function of the kidney in patients with DM type 2.<br>Materials and Methods. The groups under study consisted of 31 patients (group I) with DMSEI who received<br>proper therapy, including. xylate (3 ml/kg/h i.v, daily) and 22 patients (gr. II: APs ≥ 140 mm Hg. and/or<br>APd ≥ 90 mmHg, lizinopril 10 mg/day, during 7 days).<br>Results. In patients of group II-A sodium clearance was higher 63%, standardized excretion — 68 %, excretion<br>fraction — 72 % (p &lt; 0.05) than in patients of gr. I-A. The corresponding indicators of the osmoregulatory<br>function — clearance, standardized excretion and excretory fraction of osmotic active substances (OAS) were:<br>12 %, 13 %, 18 % (p &lt; 0.05). Xylate against a background of ACEI pharmacodynamics increased sodium clearance,<br>exceeding this indicator in the group of comparison 58 %, and OAS clearance predominated index data<br>39 % without ACEI use.<br>Conclusions. ACEI in combination with xylate interact with the volume and osmoregulatory functions of<br>the kidneys in patients with DM type 2, complicated by endogenous intoxication syndrome.</p> ER -