TY - JOUR AU - Brechka, N.M. AU - Kozar, V. V. AU - Aleksandrova, A. V. AU - Bondarenko, V. O. PY - 2019/06/13 Y2 - 2024/03/28 TI - PHARMACOLOGICAL CORRECTION OF THE INFLAMMATION IN EXPERIMENTAL PROSTATITE JF - Problems of Endocrine Pathology JA - PEP VL - 68 IS - 2 SE - DO - 10.21856/j-PEP.2019.2.12 UR - https://www.jpep.endocrinology.org.ua/index.php/1/article/view/252 SP - 81-88 AB - <p>Nowadays, the searching of etiopathogenetic factors and effective methods of treatment of non-bacterial prostatitis is actual task. The purpose of our research is to assess the impact of stimulants of metabolic pro­cesses on the inflammation by C-reactive protein concentration, white blood cells number and erythrocyte sedimentation rate in rats under the conditions of experimental prostatitis. Non-bacterial prostatitis have been caused by double rectal dosing of 1 ml of a mixture based on a 10 % solution of dimexide in water and turpentine in a 4:1 ratio (turpentine prostatitis model) to male rats. The drugs of chondroitin sulfate, chondroitin sulfate and Tribestan, Tribestan, Bioglobin-U, Prostaplant have been administrated during 14 days. The concentration of C-reactive protein have been determined using a latex reagent, the number of leukocytes - in the Goryaev chamber, erythrocyte sedimentation rate — according to the Panchenkov method. All researched drugs have anti-inflammatory properties under the conditions of turpentine prostatitis model. According to the effective­ness of reducing the concentration of C-reactive protein, leukocytosis and erythrocyte sedimentation rate , they can be placed in the following sequence: Chondroitin Sulfate, Bioglobin-U, Tribestan, Prostaplant, Chondroitin Sulfate + Tribestan (combination). In conclusion, Chondroitin Sulfate, Bioglobin-B, Tribestan, Prostaplant, Chondroitin Sulfate + Tribestan (combination) reduce the expressivenes of inflammation. Chondroitin sulfate and Bioglobin-U demonstrate more stronger anti-inflammatory properties.</p> ER -