TY - JOUR AU - Poltorak, V. V. AU - Gladkykh, O. I. AU - Mishchenko, T. V. AU - Krasova, N. S. AU - Leshchenko, Zh. A. AU - Tyzhnenko, T. V. AU - Plokhotnichenko, O. O. PY - 2021/08/18 Y2 - 2024/03/29 TI - STREPTOZOTOCIN-INDUCED TYPE 1 DIABETES MELLITUS: FORMATION MECHANISMS AND PRACTICAL ASPECTS OF EXPERIMENTAL MODELING (literature review)* JF - Problems of Endocrine Pathology JA - PEP VL - 64 IS - 2 SE - DO - 10.21856/j-PEP.2018.2.08 UR - https://www.jpep.endocrinology.org.ua/index.php/1/article/view/214 SP - 51-64 AB - <p>In the review the present-day views about mechanisms of streptozotocin-induced type 1 diabetes mellitus<br>development and methodical recommendations for its experimental modeling are presented. The mechanisms of<br>streptozotocin-induced insulin-dependent diabetes mellitus development have been considered according to four<br>ways of the diabetogen influence on β-cells:<br>1) DNA alkylating;<br>2) donating NO/NO expression intensification;<br>3) oxidative stress development;<br>4) lowering N-acetyl-β-D-glucosaminidase activity.<br>Methodical recommendations for streptozotocin-induced type 1 diabetes mellitus experimental modeling<br>are presented by the criteria:<br>1) animal species, breed, line;<br>2) animal gender;<br>3) animal age;<br>4) number of streptozotocin administrations;<br>5) recommended streptozotocin dose;<br>6) streptozotocin solution preparation;<br>7) routs of streptozotocin administration;<br>8) streptozotocin-induced type 1 diabetes mellitus correction.</p> ER -