TY - JOUR AU - Cherniaieva, A. O. AU - Mykytyuk, M. R. AU - Karachentsev, Y. I. AU - Kravchun, N. O. PY - 2019/08/28 Y2 - 2024/03/28 TI - THE RELATIONSHIP BETWEEN BLOOD LIPID PROFILE AND URICEMIA LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ACCORDING TO GENDER JF - Problems of Endocrine Pathology JA - PEP VL - 69 IS - 3 SE - DO - 10.21856/j-PEP.2019.3.11 UR - https://www.jpep.endocrinology.org.ua/index.php/1/article/view/166 SP - 83-90 AB - <p>The purpose of the study was to determine the incidence of hyperuricemia and to analyze the relationship between blood lipid profile and uric acid values in patients with type 2 diabetes mellitus according to gender. 161 patients with type 2 diabetes (67 men and 94 women) who received oral glucose-lowering therapy were examined. In the overall sample, 88 % of men and 95.7 % of women were over 50 years of age. Given the level of uric acid in the blood, patients were divided into groups: 1A (n = 43) — with blood uric acid level within the reference values for men (&lt; 420 мmol/l), 1B (n = 24) — the blood uric acid level was above the upper limit of the reference value for men (&gt; 420 мmol/l), 2A (n = 54) — with blood uric acid level within the reference values for women ( 350 мmol/l). BMI in women was significantly higher than in men (33.83 ± 6.6) and (30.83 ± 4.5) kg/m2 (P = 0.001); IOT/ OS was significantly higher in males ((1.03 ± 0.11) and (0.97 ± 0.10) cu, respectively (P = 0.003). Significantly higher levels of cholesterol were observed in women than in men ((1.17 ± 0.29) and (1.06 ± 0.16) mmol/l, respectively (P = 0.006). Hyperuricemia was diagnosed in 39.8% of patients in the total sample. Comparison of the frequency of hyperuricemia in men and women revealed no significant differences (35.8 and 42.6%, respectively). In normouricemic male patients with type 2 diabetes mellitus, the level of CHD was associated with the age and blood level of uric acid; HDL-cholesterol level — with age, disease duration and blood level of uric acid; TG level — with the level of uric acid in the blood. In normouricemic female patients with type 2 diabetes mellitus, CSF level was associated with HbAc1 level; the level of HDL-cholesterol — with age and BMI; TG level — with the blood level of uric acid. The level of HDL-cholesterol was associated with hyperuricemia in male patients with type 2 diabetes mellitus. The level of CHD, HDL-cholesterol and TG were independently associated with the level of glycemic control of the disease in «hyperuricemic» female patients with type 2 diabetes mellitus.</p> ER -