@article{Bohdan_Lizogub_Sobol_Bohdan_2021, title={THE ROLE OF BETA-BLOCKERS IN VETIANGINAL THERAPY IN THE CORRECTION OF VIOLATIONS OF THE AMINO ACID SPECTRUM IN PATIENTS WITH UNSTABLE ANGINA WITH CONCOMITANT DIABETES MELLITUS}, volume={77}, url={https://www.jpep.endocrinology.org.ua/index.php/1/article/view/937}, DOI={10.21856/j-PEP.2021.3.03}, abstractNote={<p>The purpose of the study: to study the effect of bisoprolol and nebivolol on the spectrum of essential blood&nbsp;plasma AK in patients with concomitant diabetes mellitus (DM) type 2 in order to optimize drug treatment of&nbsp;this pathology in the future.<br>Material and methods. The study involved 70 patients with NA with concomitant DM type 2, which was&nbsp;divided into two groups: group I (37 patients) as part of basic antianginal therapy received bisoprolol, group II&nbsp;(33 patients) received nebivolol. The control group (CG) consisted of 18 healthy individuals. All patients were&nbsp;tested for irreplaceable blood plasma AA by ion exchange liquid chromatography on an automatic analyzer AK&nbsp;T-339 produced by «Microtechna» (Czech Republic, Prague) at the Institute of Biochemistry named after OV&nbsp;Palladin NAMS of Ukraine. The following essential AAs were identified: arginine, valine, histidine, isoleucine,&nbsp;leucine, lysine, methionine, threonine, phenylalanine. Examination of patients was performed at the beginning&nbsp;of treatment and after 20 days.&nbsp;Results. It was determined that in patients with NA with concomitant DM type 2 under the influence of&nbsp;antianginal therapy in both groups significantly decreased the total amount of irreplaceable AA compared with&nbsp;control group, indicating an increase in intracellular metabolism as a compensatory response in coronary circulation.&nbsp;It should be noted that in patients of group II, in contrast to patients of group I, under the influence of&nbsp;treatment the level of histidine remained normal. The level of threonine significantly decreased compared to CG&nbsp;and the rate of patients in group I, the level of valine significantly increased compared to pre-treatment, the level&nbsp;of isoleucine significantly decreased compared with CG and with the rate of patients of group I. Importantly,&nbsp;ammonia levels returned to normal under the influence of basic therapy, which included nebivolol.<br>Conclusion. The dynamics of changes in the levels of individual irreplaceable AA blood plasma, due to&nbsp;the mechanisms of their metabolic transformations in patients with NA with concomitant DM type 2 indicates&nbsp;greater effectiveness of nebivolol and the feasibility of its prescription іn complex of a basic antianginal therapy.</p>}, number={3}, journal={Problems of Endocrine Pathology}, author={Bohdan, Tetiana and Lizogub, Viktor and Sobol, Viktoriia and Bohdan, Viktor}, year={2021}, month={Sep.}, pages={24-30} }