@article{Khyzhnyak_Tykhonova_Barabash_2021, title={ASSESSMENT OF INSULIN PRODUCTED PANCREATIC FUNCTION IN PATIENTS WITH DIABETES MELLITUS WITH DIFFERENT DEGREES OF INSULIN DEFICIENCY}, volume={58}, url={https://www.jpep.endocrinology.org.ua/index.php/1/article/view/402}, DOI={10.21856/j-PEP.2016.4.06}, abstractNote={<p>The study involved 162 people, including 61 patients with type 1 diabetes mellitus (DM), 70 patients with slowly progressive autoimmune diabetes of adults and 31 patients with type 2 diabetes with the development of insulin dependence after more than 10 years since the disease onset. Based on a comparative analysis of fasting C-peptide levels in patients of observation groups the different degree of insulin secretion reduction was set. Thus in patients with type 1 diabetes mellitus severity of absolute insulin deficiency is not a determining factor of the variant of the disease (relatively stable or labile). In general, the definition of C-peptide in patients with diabetes is a reliable criterion by which we can judge the functional activity of β-cells, even in the appointment of insulin. In doubtful cases it is advisable to carry out the research of C-peptide in the dynamics of observation.</p>}, number={4}, journal={Problems of Endocrine Pathology}, author={Khyzhnyak, O. O. and Tykhonova, T. M. and Barabash, N. E.}, year={2021}, month={Jun.}, pages={42-48} }