@article{Guda_Pushkarev_Zhuravel_Kovalenko_Tarachenko_Tronko_2021, title={RET/PTC1/3 AND BRAF W T/MUT mRNA E XPRESSION IN TUMORS OF THE HUMAN THYROID}, volume={60}, url={https://www.jpep.endocrinology.org.ua/index.php/1/article/view/297}, DOI={10.21856/j-PEP.2017.2.05}, abstractNote={<p>There were studied the chromosomal translocation of receptor tyrosine kinase gene RET/PTC1, RET/PTC3,<br>gene mutations of protein kinase B-RAF (BRAFV600E) and the expression of BRAFwt in the multinodular<br>goiter tissue, follicular and papillary carcinoma of the human thyroid. Of the 29 tissue samples which were<br>studied, changes in the expression, gene mutations and rearrangements were detected in 11 cases (38 %). In one<br>tumor sample of papillary carcinoma double rearrangement of the gene RET — RET/PTC1 and RET/PTC3 was<br>found. In a more aggressive invasive tumors the expression level RET/PTC1 and RET/PTC3 was higher than<br>in encapsulated tumors. It was observed the increased expression of protein kinase BRAF (BRAFwt) in some<br>samples of tumor tissue of follicular carcinoma and multinodular goiter.<br>The significance of MAPK signaling pathway in tumors of the thyroid was discussed.</p>}, number={2}, journal={Problems of Endocrine Pathology}, author={Guda, B. B. and Pushkarev, V. M. and Zhuravel, O. V. and Kovalenko, A. Ye. and Tarachenko, Y. M. and Tronko, M. D.}, year={2021}, month={Aug.}, pages={31-37} }