@article{Koreneva_Philimonova_Brechka_Chistyakova_Smolyenko_Belkina_Karpenko_2019, title={MODELING OF CHRONIC PROSTATITIS. ABACTERIAL PROSTATITIS IN THE ASPECTS OF REPRODUCTION OF EXPERIMENTAL HYPOFERTILITY (review)}, volume={67}, url={https://www.jpep.endocrinology.org.ua/index.php/1/article/view/232}, DOI={10.21856/j-PEP.2019.1.13}, abstractNote={<p>There is a problem of modeling of prostatitis in animals despite of the progress at the creation of prostatic protectors capable of correcting hypofertility. In this regard, modeling prostate gland pathology, monitoring its development and finding out factors causing a decrease in the generative function in prostatitis are topical issues. In this review, the important role of experimental modeling of prostatitis have been shown, the etiology, pathogenesis and clinical manifestations of prostatitis, the epidemiology of reproductive impairment in conditions of abacterial inflammatory process of the prostate gland have been reviewed, and data about methods of prostatitis modelling in laboratory animals. Such modeling of chronic abacterial prostatitis in rats has been reviewed: by rectal administration of dimexide and turpentine; by cryotrauma; piercing (traumatic) prostatitis; prostatitis after hypokinetic stress; autoimmune prostatitis; acute aseptic inflammation of the prostate gland; chronic prostatitis by applying metaxylene; as well as experimental models of prostatitis associated with hormonal effects. Summarizing the literature data, the authors conclude that the experimental modeling of chronic prostatitis is an issue of importance not only for the study of the course of this common disease, but also for the development of new methods and measures for the treatment of prostatitis and reproductive health disorders that occur on the background or accompanied by inflammation.</p>}, number={1}, journal={Problems of Endocrine Pathology}, author={Koreneva, E. M. and Philimonova, N. I. and Brechka, N. M. and Chistyakova, E. E. and Smolyenko, N. P. and Belkina, I. O. and Karpenko, N. O.}, year={2019}, month={Mar.}, pages={104-115} }