@article{Жердьова_Маньковський_Лісун_Древицька_Костицька_2019, title={INFLUENCE METFORMIN ON THE STATE OF THE ANTIOXIDANT SYSTEM IN PATIENTS WITH NEWLY DIABETES MELLITUS TYPE 2}, volume={70}, url={https://www.jpep.endocrinology.org.ua/index.php/1/article/view/150}, DOI={10.21856/j-PEP.2019.4.06}, abstractNote={<p>The article presents data on the state of the antioxidant system in patients with newly diabetes mellitus<br>type 2. The aim of our work was to determine the effect of metformin on the state of the antioxidant system<br>in patients with newly diagnosed type 2 diabetes. The study included 60 patients with newly diagnosed type 2<br>diabetes mellitus (43 women and 17 men). The average age of the patients was 60.91 ± 1.42 years, the level of<br>HbA1c was 7.91 ± 0.17 %. It was found that at the time of diagnosis of diabetes mellitus, a decrease in the level<br>of indicators of the antioxidant defense system, namely catalase by 3.5 times and glutathione peroxidase by<br>1.7 times in comparison with the control group, was already detected. After the course of treatment with metformin in the maximum tolerated dose (the average dose was 2000 mg per day), we received not only an improvement in metabolic control, namely a decrease in the level of glycated hemoglobin to 6.63 ± 0.11 % (p ≤ 0.05), but<br>also already after 3 months of treatment, improving the status of the antioxidant defense system by increasing<br>the levels of catalase and glutathione peroxidase enzymes, and therefore leads to a decrease in oxidative stress<br>and, as a result, a decrease in the development of complications of type 2 diabetes. In the study, we used three<br>metformin of various manufacturers as the first line of treatment in patients with newly diagnosed diabetes and<br>did not receive a significant difference in metabolic control, pro and antioxidant systems</p>}, number={4}, journal={Problems of Endocrine Pathology}, author={Жердьова, Н. М. and Маньковський, Б. М. and Лісун, Ю. Б. and Древицька, Т. І. and Костицька, І. М.}, year={2019}, month={Nov.}, pages={45-51} }