THE FERTILITY OF RATS FEMALES - OFFSPRING BORN TO MOTHERS WITH FETOPLACENTAL INSUFFICIENCY

Authors

  • Seliukova N. Yu. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine; National Pharmaceutical University, Ministry of Health of Ukraine, Kharkiv, Ukraine
  • Korenieva Ye. M. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Kustova S. P. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Boiko M. O. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Misiura K. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2020.4.18

Keywords:

fecundity of females-offspring, fetoplacental insufficiency, sex hormones, pharmaceutical composition

Abstract

The penetration of the toxic substances into mother's organism leads to the cumulative xenobiotic burden of different degree with the following induction of removal reactions and developing of obstetric complications, and may cause the metabolic form of fetoplacental insufficiency. The pathogenesis of the fetoplacental insufficiency is determined by morphological changes and disturbances of placenta functioning. The purposes of this work were to study influence of further consequences of experimental fetoplacental insufficiency in mothers of young and mature reproductive age on the females-offspring fertility and to investigate the protective properties of original pharmaceutical composition.Materials and methods. The healthy, Vistar mature rat's females of young (3 months) and mature (10 months) reproductive age have been used in the experiment. 8 groups for 7 pregnant females in each have been formed: groups 1 and 2 — intact animals of young and mature reproductive age; groups 3 and 4 — females with experimental fetoplacental insufficiency of young and mature reproductive age accordingly; groups 5 and 6 — young and mature animals with experimental fetoplacental insufficiency treated by pharmaceutical composition from 11 to 19 day of pregnancy. Groups 7 and 8 — young and mature animals with experimental fetoplacental insufficiency treated by drug of comparison – Dipyridamole. The modeling of fetoplacental insufficiency has been fulfilled by daily subcutaneous introduction of 50% tetrachloromethane oil solution in dose of 2 ml/kg of body mass from 12 to 18 day of pregnancy. The fertility of females has been determined according to the results of mating with intact healthy males. The blood serum samples have been obtained for Estradiol and Testosterone levels determination.Results. Fetoplacental insufficiency influences the fertility of females-offspring born to mothers of young and mature reproductive age. Аll the groups of females-offspring born to mothers with fetoplacental insufficiency have significantly lowered pregnancy index and integral fecundity. Only in offspring born to mothers of young reproductive age with fetoplacental insufficiency the decreased number of pregnancy corpus luteum, implantation sites and fetuses has been observed. The introduction of pharmaceutical composition to pregnant females has lead to female birth with normalized levels of sex hormones, nevertheless, animals has demonstrated decreased fecundity.

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Published

2020-11-12

How to Cite

Seliukova, N. Y., Korenieva, Y. M., Kustova, S. P., Boiko, M. O., & Misiura, K. V. (2020). THE FERTILITY OF RATS FEMALES - OFFSPRING BORN TO MOTHERS WITH FETOPLACENTAL INSUFFICIENCY. Problems of Endocrine Pathology, 74(4), 138-146. https://doi.org/10.21856/j-PEP.2020.4.18

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