THE ASSOCIATIONS OF T344C SINGLE NUCLEOTIDE POLYMORPHISM OF ALDOSTERONE SYNTHASE GENE CYP11B2 (RS1799998) WITH CLINICAL , HAEMODYNAMIC AND METABOLIC FE ATURES OF PATIENTS WITH ARTERIAL HYPERTENSION AND ABDOMINAL OBESITY

Authors

  • Koval S. M. GI «L. T. Malaya Therapy National Institute of the NAMS of Ukraine», Kharkiv, Ukraine
  • Miloslavsky D. K. GI «L. T. Malaya Therapy National Institute of the NAMS of Ukraine», Kharkiv, Ukraine
  • Snegurska I. A. GI «L. T. Malaya Therapy National Institute of the NAMS of Ukraine», Kharkiv, Ukraine
  • Mysnychenko O. V. GI «L. T. Malaya Therapy National Institute of the NAMS of Ukraine», Kharkiv, Ukraine
  • Penkova M. Yu. GI «L. T. Malaya Therapy National Institute of the NAMS of Ukraine», Kharkiv, Ukraine
  • Schenyavska E. N. GI «L. T. Malaya Therapy National Institute of the NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2020.2.05

Keywords:

arterial hypertension, abdominal obesity, single nucleotide polymorphism, aldosterone synthase gene.

Abstract

The aim: To study the association between T344C single nucleotide polymorphism (SNP) of aldosterone
synthase (ALS) gene CYP11B2 (rs1799998) with anthropometric, clinical, haemodynamic, structural and metabolic parameters of patients with arterial hypertension (AH) and abdominal obesity (AO).
Materials and methods: 112 patients with AH II stage, 2–3 degrees with AO aged 45–69 years were surveyed. Control group is composed of 28 healthy city residents of the appropriate age and gender. Haemodynamic
parameters, blood glucose levels, glucose tolerance test, the expanded lipid spectrum, aldosterone levels were
evaluated. Genotyping of T344C SNP of ALS gene CYP11B2 was performed by polymerase chain reaction in
real-time. Statistical data processing was carried out using SPSS packages.
Results: The distribution of T344C SNP genotypes of ALS gene CYP11B2 among healthy individuals and
patients with AH and AO does not significantly differ and is similar to that in the European population. The
serum level of HDL-C in patients with TT genotype was significantly higher than in patients with TC genotype
(p = 0.01). The association between TT + TC genotypes of ALS gene CYP11B2 and left ventricular hypertrophy
(LVH) (p < 0.05) in the examined patients was shown. The significant direct correlations between «hypertensive» T allele of aldosterone synthase gene frequency and the duration of AH and the severity of LVH were
found.
Conclusions: The associations between TT + TС genotypes T344C SNP of ALS gene, and the presence of
LVH as well as between TT genotypes and elevated serum level HDL-C in AH patients with AO were established.

References

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Published

2021-06-30

How to Cite

Koval, S. M. ., Miloslavsky D. К. ., Snegurska, I. A. ., Mysnychenko, O. V. . ., Penkova, M. Y. . ., & Schenyavska . Е. N. . . (2021). THE ASSOCIATIONS OF T344C SINGLE NUCLEOTIDE POLYMORPHISM OF ALDOSTERONE SYNTHASE GENE CYP11B2 (RS1799998) WITH CLINICAL , HAEMODYNAMIC AND METABOLIC FE ATURES OF PATIENTS WITH ARTERIAL HYPERTENSION AND ABDOMINAL OBESITY. Problems of Endocrine Pathology, 72(2), 44-50. https://doi.org/10.21856/j-PEP.2020.2.05

Issue

Section

CLINICAL ENDOCRINOLOGY