MONOCYTE CHEMOATTRACTANT PROTEIN-1 LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND CORONARY ARTERY DISEASE
Keywords:coronary artery disease, type 2 diabetes mellitus, monocyte chemoattractant protein-1
Background. Mechanisms of atherosclerotic cardiovascular diseases in patients with diabetes mellitus have not been fully clarified. Monocyte chemoattractant protein-1 (MCP-1) is a proinflammatory chemokine which plays a key role in the pathophysiology of both atherosclerosis and diabetes.
The aim of the study was to investigate MCP-1 levels in patients with coronary artery disease (CAD) with type 2 diabetes mellitus (T2DM) depending on previous history of myocardial infarction and percutaneous coronary intervention (PCI).
Materials and Methods. Serum MCP-1 levels were measured in 31 patients with stable CAD with T2DM, 26 non-DM patients with CAD, and 15 control group persons.
Results. MCP-1 level in patients with CAD with T2DM was higher than in the control group (p=0,0007) and non-DM patients with CAD (р=0,039). The elevation of MCP-1 level in non-DM patients with CAD was insignificant. There were no correlations of MCP-1 levels with glucometabolic and lipid indices in any groups. MCP-1 levels did not differ significantly in CAD patients with and without a history of previous myocardial infarction both in non-DM patients and in patients with T2DM. CAD patients with T2DM with a history of PCI more than 1 year previously have higher MCP-1 levels than CAD patients with T2DM without a history of PCI (p=0,038). In non-DM patients with CAD with the same history of PCI MCP-1 decreased compared to non-DM patients without previous PCI (p=0,030).
Conclusions. In patients with CAD with T2DM MCP-1 level increased in comparison with the controls and CAD patients without T2DM. CAD patients with T2DM with a history of PCI have highest MCP-1 level.
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