PHYTOESTROGENS EFFECT ON SEXUAL HORMONES LEVEL AND FERTILITY OF RATS

Authors

  • Somova E. V. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Gladkova A. I. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Karpenko N. A. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Koreneva E. M. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv https://orcid.org/0000-0002-4570-6563
  • Chistyakova E. E. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv https://orcid.org/0000-0003-1441-0804
  • Selyukova N. Yu. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv https://orcid.org/0000-0001-9657-6888

DOI:

https://doi.org/10.21856/j-PEP.2010.1.13

Keywords:

phytoestrogens, estradiol, testosterone, spermatozoa, oocytes, embryos, implantation

Abstract

The influence of 30-day application of phytoestrogens compound to postpubertal male and female rats on the level of sexual hormones, gametes maturation and fertilization capacity was experimentally studied. Long-term phytoestrogenes supplies into animal’s organism bring out substantial changes in the level of sexual hormones. In females different estradiol contents are levelled at the estrus-diestrus stages that is typical for intact females. In males there was a considerable increase of estradiol, in a lesser degree — testosterone. Hence, the testosterone-esrtadiol ratio is altered. Morphological structural changes in male and female gametes, decreased spermatozoa motility, impaired embryonic implantation, a high rate of embryonic mortality are observed.

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Published

2010-03-03

How to Cite

Somova, E. V., Gladkova, A. I., Karpenko, N. A., Koreneva, Y., Chistyakova, E., & Selyukova, N. (2010). PHYTOESTROGENS EFFECT ON SEXUAL HORMONES LEVEL AND FERTILITY OF RATS . Problems of Endocrine Pathology, 31(1), 86-93. https://doi.org/10.21856/j-PEP.2010.1.13

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