HORMONE-ASSOCIATED METABOLIC DISORDERS OF THE ORAL CAVITY ORGANS IN WOMEN OF REPRODUCTIVE AGE

Authors

  • Khodorovskyi G. I. Bukovinian State Medical University
  • Panina L. V. Danylo Halytsky Lviv National Medical University https://orcid.org/0000-0002-7098-205X
  • Shchurko T. S. Danylo Halytsky Lviv National Medical University

DOI:

https://doi.org/10.21856/j-PEP.2021.4.17

Keywords:

органи ротової порожнини, репродуктивні органи, статеві гормони, слина, грелін

Abstract

There is emerging evidence of a possible relationship between the oral cavity and reproductive organs. Recent studies suggest these functional relations. The aim of this review was to synthesize the available evidence on this relationship. Clinical observation established that sex hormones enhance gingival inflammation in periodontal healthy women during pregnancy and that periodontal condition is associated with variation of sex hormones in blood. Estrogen regulates DNA synthesis in human gingival epithelial cells and periodontal ligament, estrogen reduces down regulation of cytokines. Estrogen and progesterone affect the periodontium via appropriate receptors (estrogen receptor and progesterone receptor). They are localized in human periodontium, demonstrating that periodontal tissues are the target tissues for these hormones.

Testosterone receptors are found in the periodontal tissues. It inhibits prostaglandin secretion and reduces interleukin production. At the same time testosterone stimulates osteoblast proliferation and differentiation, also enhances matrix synthesis by fibroblast, osteoblasts, and periodontal ligament. The role of testosterone in the formation of teeth is demonstrated in the paper.

In females and males, in saliva there are sex steroid hormones. The study examined the entry mode of hormones into saliva. The results suggest that lipid soluble unconjugated steroids (estriol, testosterone, progesterone) enter saliva via intracellular route; the conjugated steroids (lipid insoluble (dehydroepiandrosterone, conjugated estrogens)) enter via the ‘tight junctions’ (infiltrations through the tight junctions between the acinar cells).

Recent evidence indicates that organs of the oral cavity (salivary glands, periodontal tissues, oral epithelial cells mucus) produce ghrelin-hormone which affects organs of the reproductive system directly or indirectly via hypothalamic-pituitary-gonadal axis. In all these organs, there is an appropriate receptor. In conclusion, the organs of oral cavity and organs of reproductive system are functionally linked by sex steroid hormones and ghrelin, besides that periodont can influence ovaries by neuro-reflectory link.

 

References

Min Wu, Shao-Wu Chen, Shao-Yun Jiang. Mediators of inlamation 2015; 11.

Min Wu, Shao Wu Chen, Wei Lan Su, Hong-Ying Zhu. Mediators of inflammation 2016; 6.

Zachariasen RD. Women and Health 1993;20(2): 21-30.

Reynolds MA, Aberdeen GW, Pepe GI, et al. J Periodontol 2004;75(5): 693-701.

Güncü GN, Tözüm TF, Çaglayan F. Australian Dental J 2005;50(3):138-145.

Yokoyama D, Hinode K, Masuda M, Yoshioka D. Oral Microbiol Immunol 2005;20(4): 239-243.

Miyagi M, Morishita M, Iwamoto Y. J Periodontol 1993;64(1): 1075-1078.

Morishita M, Miyagi M, Iwamoto Y. J Periodontol 1999;70(7): 557-760.

Plancak D, Visher B, Jordic-Srdjak K, Slaj K. Coll Antropol 1998;22(Suppl): 51-55.

Ottomo-Corgel J, Steinberg BJ. Periodontal medicine and the female patients, Hamilton, 2000: 151-167.

Pack ARC, Thomson ME. J Clin Reriodontal 1980;7: 402-414.

Thomson ME, Pack ARC. J Clin Reriodontal 1982;9: 275-280.

Mlyagi M, Aoyoma H, Morishita M. Iwamoto Y. J Periodontol 1992;63: 28-32.

Holm-Pederson P, Loe H. J Periodontal Res 1967;2: 13-20.

Saxen J. Clin Genet 1984;25: 232-335.

Hosseni FA, Tirgarri F, Shaigan S. Iran J Public Healt 2006;35: 38-41.

Markou E, Eleana B, Lazarrous T, Antonios K. Open Dent J 2009;3: 114-119.

Vivek MR, Hernandez EJ, Wenk SC. J Clin Endocrinol Metabol 1982;54(3): 608-612.

Kawahara K, Shimazu A. J Periodontal Res 2003;38(3): 242-246.

Jőnsson D, Anderson G, Ekblad M, et al. Arch Oral Biol 2007;52(7): 669-676.

Välimaa H, Savolainen S, Soukka T. J Endocrinol 2004;180(1): 55-62.

Nebel D, Bratthall G, Ekblad E, et al. J Periodont Res 2011; 46(5): 622-628.

Jönson D, Wahlin A, Idvall I, et al. J Periodontal Res 2005;40(5): 401-406.

Yuan G, Cai C, Dai D. Calcified Tissue Internat 2010;87(2): 158-167.

Kawamoto A, Sugano N, Matohashi I, Matsumoto S. J Periodontal Res 2012;47(5): 593-598.

Nirola A, Batra P. J Int Clin Dent 2018;10: 3-11.

Deepa MS. IJWDC 2013;1: 15-20

Vining F, McGinley A, Rice BV. J Clin Endocrinol Metab 1983;58: 454.

Parkar M, Tabona P, Newman H, Alsen I. Cytokine 1998;10(8): 613-619 .

Gornstein RA, Lapp CA, Bustos-Valdes SM, Zamorano P. J Periodont 1999;70(6): 604-609.

Tawfik MA, Elattarhsien S, Lin Daniel E. Leukotrienes Med 1982;9(1): 25-34.

Ribeiro DC, Brook AH, Hughes TE, et al. J Dent Res 2013;92(5): 425-431.

Schipper RG, Silletti E, Vingerhoeds MH. Arch Oral Biol 2007;52: 1114-1135.

Riad-Fahmy D, Read GF, Walker RF, Griffiths K. Endocr Rev 1982;3: 367-395.

Vining Ross F, Robynne Mc Ginley, Richard G. Symons. Clin Chem 1983;29(10): 1752-1756.

Zolotukhin S. Oral Dis 2013;19(3): 219-229.

Grőschi M. Bioessays 2009;31(8): 843-852.

Fisher HE. Anatomy of love : a natural history of mating, marriage, and why we stray, New York, 2017: 464 p.

Vining RF, Mc Gienley RA, Symons RG. Clin Chem 1983;29(10): 1752-1756.

Ohta K, Laborde NJ, Kajiya M, et al. J Dent Res 2011;90(11): 1286-1292.

Groshe M, Topf HG, Bohlender J, et al. Clin Chem 2005;51: 997-1000.

Tropea A, Tibery F, Minici F, et al. J Clin Endocrinol Metab 2007;92(8): 3239-3245.

Leung PK, Chow KBS, Lan PN. Cell Signalling 2007;19(5): 1011-1022.

Geelissen SME, Back IME, Darras VM, et al. General Comp Endocrinol 2003;134(2): 167-174.

Tanaka M, Miyazaki T, Yamamoto I, et al. General Comp Endocrinol 2003;134(2): 198-202.

Saito ES, Kelya H, Toshibana T, et al. Regulatory Peptides 2005;125(1-3): 201-208.

Richards MP, Poch SM, Mc Murtry JP. General Comp Endocrinol 2006;145(3): 298-310.

Granapavan S, Kola B, Bustin SA, et al. J Clin Endocrinol Metab 2002;87(6): 2988-2991.

Lugue RM, Park S, Peng XD, et al. J Mol Endocrinol 2004;32(2): 437-448.

Kojima M, Hosoda H, Date Y, et al. Nature 1999;402: 656-660.

Dupont J, Maillard V, Coyral-Castel S, et al. Int J Peptides 2010;8.

Lebrethon MC, Aganina A, Fournier M, et al. J Neuroendocrinol 2007;19(3): 181-188.

Vulliemoz NR, Xiao E, Xia-Zhang I, et al. Endocrinology 2008;149(3): 869-874.

Lafranko I, Bonelli M, Baldi M, et al. J Clin Endocrinol Metab 2008;93(9): 3633-3639.

Messini CI, Dafopoulos K, Chalvatras N, et al. Human Reprod 2009;24(4): 976-981.

Tena-Sempere M, Bareiro MI, Gonzales LC, et al. Endocrinology 2002;143(2): 717-725.

Gaytan, Barreiro MIC, Caminos JE, et al. J Clin Endocrinol Metab 2004;89(1): 400-409.

Millen DW, Harrison JI, Brown YA, et al. Reprod Biol Endocrinol 2005;3 (article 60).

Garcia MC, Lopez M, Alvares CV, et al. J Reprod 2007;133(3): 531-540.

Sirotkin AV, Chrenkova M, Nitrayova S, et al. Peptides 2008;29(8): 1362-1368.

Kheradmand A, Roshangar I, Taati M, Sirotkin AV. Tissue Cell 2009;41(5): 311-317.

Viami I, Vottero A, Tassi F, et al. J Clin Endocrinol Metab 2008;93(4): 1476-1481.

Tropea A, Tiberi F, Minici F, et al. J Clin Endocrinol Metab 2007;92(8): 3239-3245.

Vulliemoz NR, Xiao E, Xia-Zhang I, et al. J Endocrinol 2008;149(3): 869-874.

Messini CI, Dafopoulos K, Chalvatzas N, et al. Human Reprod 2009;24(4): 976-981.

Lafranko F, Bonelli I, Baldi M, et al. J Clin Endocrinol Metab 2008;93(9): 3633-3639.

Kawamura K, Sato N, Fukuda J, et al. J Endocrinol 2003;144(6): 2623-2633.

Gualillo O, Caminos J, Blanko M, et al. J Endocrinol 2001;142: 788-794.

Downloads

Published

2021-12-03

How to Cite

Khodorovskyi, G., Panina, L., & Shchurko, T. (2021). HORMONE-ASSOCIATED METABOLIC DISORDERS OF THE ORAL CAVITY ORGANS IN WOMEN OF REPRODUCTIVE AGE. Problems of Endocrine Pathology, 78(4), 127-134. https://doi.org/10.21856/j-PEP.2021.4.17