THE ROLE OF SINGLE NUCLEOTIDE POLYMORPHISM +45T/G OF ADIPONEKTIN GENE (ADIPOQ) IN RISK OF TYPE II DIABETES MELLITUS DEVELOPMENT

Authors

  • Karachentsev Yu. I. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0003-1317-6999
  • Gorshunska M. Yu. Kharkiv Postgraduate Medical Academy https://orcid.org/0000-0002-4402-9441
  • Atramentova L. O. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Kravchun N. A. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Khizhnyak O. O. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0002-4541-5248
  • Tyzhnenko T. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Grinchenko T. S. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Gladkih A. I. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Leshchenko Z. A. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0002-6141-689X
  • Shevchenko Y. A. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Pochernyaev A. K. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Romanova I. P. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Poltorak V. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2010.4.01

Keywords:

single nucleotide polymorphism, adiponectin, gene, genotypes frequency, insulin resistance, type 2 diabetes mellitus

Abstract

Single nucleotide polymorphism (SNP) +45T/G gene of adiponectin (ADIPOQ) in type 2 diabetes mellitus patients and in healthy residents of Kharkiv has been taken into consideration. Frequencies of SNP +45T/G for patients (pG = 0,48; pT = 0,52) and healthy residents(pG = 0,49; pT = 0,51) do not differ significantly. The genotypes frequency in control group doesn’t correspond to HardyWeinberg equilibrium: the share of heterozygotes +45T/G is 1,8 times higher than selectively-neutral value. The type II diabetes mellitus patients have the share of heterozygotes +45T/G one third lower than in control group. The analysis has shown that heterozygotes genotype reduces the risk of type 2
diabetes mellitus in seven times (p < 0,05) in comparison with a mean value in population.

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Published

2010-12-28

How to Cite

Karachentsev, Y., Gorshunska, M., Atramentova, L. O., Kravchun, N. A., Khizhnyak, O., Tyzhnenko, T. V., Grinchenko, T. S., Gladkih, A. I., Leshchenko, Z., Shevchenko, Y. A., Pochernyaev, A. K., Romanova, I. P., & Poltorak, V. V. (2010). THE ROLE OF SINGLE NUCLEOTIDE POLYMORPHISM +45T/G OF ADIPONEKTIN GENE (ADIPOQ) IN RISK OF TYPE II DIABETES MELLITUS DEVELOPMENT. Problems of Endocrine Pathology, 34(4), 5-13. https://doi.org/10.21856/j-PEP.2010.4.01

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Section

CLINICAL ENDOCRINOLOGY

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