EXPERIENCE OF THE THERAPY OF HYPOANDROGEN MALE INFERTILITY WITH TAMOXIFEN — AEVIT COMBINATION

Authors

  • Kozhemyaka V. A. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Bondarenko V. O. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0002-9254-3875
  • Minuchin A. S. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0003-2524-7512

DOI:

https://doi.org/10.21856/j-PEP.2010.2.07

Keywords:

idiopathic pathospermias, aevit, tamoxifen, testosterone-luteinizing hormone ratio, fructose

Abstract

Studies into peculiar changes of spermatogram parameters, fructose content in ejuaculate and hormonal levels of hypophysic-gonadal system using the therapy of idiopathic pathospermias in hypoandrogenized males treated with Tamoxifen-Aevit combination have been performed. The applied therapy led to a profound improvement of spermatogram parameters, testosterone secretion stimulation, increased fructose concentration in ejaculate. Tamoxifen combined with Aevit had a more substantial influence upon normalization of all spermatogram parameters of infertile males when prior to their treatment the testosterone-luteinizing hormone ratio exceeded 2,0.

References

Medical treatment to improve sperm quality [Text] / A. M. Isidori, C. Pozza, D. Gianfrolli [et al.] // Reproductive Bio Medicine Online. — 2006. — Vol. 12, Comp.1. — P. 23–33.

Chatterjee S. Medical management of male infertility [Text] / S. Chatterjee, R. G. Chowdpury, B. Khan // J. Indian. Mes. Assoc. — 2006. — Vol. 104, № 2. — P. 76–77.

Kumar R. Drug therapy for idiopathic male infertility: rational versus evidens [Text] / R. Kumar, G. Gantam, N. P. Gupta // J. Urol. — 2006. — Vol. 176, № 4, Pt. 1. — P. 1307–1312.

Сапсай В. И. Мужское бесплодие [Текст] / В. И. Сапсай, Л. П. Имшинецкая, А. В. Сапсай ; под ред. И. И. Горпинченко. — К.: Аврора плюс, 2005. — 84 с.

Treatment of idiopathic oligozoospermia with tamoxifen [Text] / C. Brigante, G. Motta, F. Tusi [et al.] // Acta Europ. Fertil. — 1985. — Vol. 16, № 5. — P. 361–364.

Михайличенко В. В. Бесплодие у мужчин [Текст]: руководство по андрологии / В. В. Михайличенко; под ред. О. Л. Тиктинского. — Л. : Медицина, 1990. — С. 297–335.

Improvement in semen quality in infertility males after treatment with tamoxifen [Text] / D. I. Levis-Jones, R. V. Lynch, D. C. Machin [et al.] // Andrologia. — 1987. — Vol. 19, № 1. — P. 86–90.

Hormonal changes in tamoxifen treated men with idiopathic oligozoospermia [Text] / R. Hampl, J. Heresova, J. Sulcova [et al.] // Exp. Clin. Endocrinol. — 1988. — Vol. 92, № 2. — P. 211–216.

Push H. H. Ergebnisse niedrig — dosierter Therapie mit Clomiphen zitrat bie oligozoospermie [Text] / H. H. Push, J. Yaas, P. Pürstner // Andrologia. — 1986. — Vol. 18, № 1. — P. 561–566.

Treatment of idiopathic and postvaricocelectomy oligozoospermia with oral tamoxifen citrat [Text] / T. C. Kadioglu, I. T. Koksal, M. Tunc [et al.] // BJU Int. — 1999. — Vol. 83, № 6. — P. 646–648.

Liu P. Y. The present and future state of hormonal treatment for male infertility [Text] / P.Y. Liu, D. ˙ J. Handelsman // Human. Reprod. Update. — 2003. — Vol. 9, № 1. — P. 9–23.

WITHDRAWN: Clomiphen of tamoxifen for idiopathic oligo/astenospermia [Text] / P. Vandtkerckhove, R. Lilford, A. Vail [et al.] // Cochrane Data base Syst. Rev. — 2007. — Vol. 18, № 4. — P. CD000151.

Частота случаев андрогенодефицита у мужчин разного возраста при идиопатической гипофертильности [Текст] / В. А. Бондаренко, Н. А. Карпенко, В. А. Кожемяка [и др.] // Ендокринна патологiя у вiковому аспектi : матерiали наук.-практ. конф. з мiжнар. участю, Харкiв, 29–30 листоп. 2007 р. — Х., 2007. — С. 14–15.

Гладкова А. И. Влияние гиперэстрогенемии на формирование патоспермии у мужчин [Текст] / А. И. Гладкова, В. А. Бондаренко // Здоровье мужчины. — 2003. — № 2. — С. 95–99.

Лучицький Є. В. Чоловiчий гiпогонадизм: сучаснi пiдходи до лiкування [Текст] / Є. В. Лучицький, В. О. Бондаренко // Ендокринологiя. — 2007. — Т. 12, № 1. — С. 154–166.

Downloads

Published

2010-06-09

How to Cite

Kozhemyaka, V. A., Bondarenko, V., & Minuchin, A. (2010). EXPERIENCE OF THE THERAPY OF HYPOANDROGEN MALE INFERTILITY WITH TAMOXIFEN — AEVIT COMBINATION. Problems of Endocrine Pathology, 32(2), 49-54. https://doi.org/10.21856/j-PEP.2010.2.07

Issue

Section

CLINICAL ENDOCRINOLOGY

Most read articles by the same author(s)

1 2 > >>