OBESITY AND OSTEOPATHY - EMBRYONIC DETERMINISTIC LEPTIN-ASSOCIATED DISEASES (Literature review, own data and hypotheses)

Authors

  • Sergiyenko L. Yu. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2011.2.13

Keywords:

epidemiological studies

Abstract

The results of large-scale epidemiological studies, constantly conducted under the auspices of the World Health Organization in both developed and developing countries, show that, despite the convincing advances made in understanding the etiology and pathogenesis of most diseases, the ongoing diagnosis of drugs, the overall health of the planet's population is declining, and then a small number of years for which MA uvelychyvaetsya srednyaya Duration life, otyahoschaetsya mnohochyslennыmy diseases.

References

Socioeconomic status and obesity in adult populations of developing countries: a review [Text] / C. A. Monteiro, E. C. Moura, W. L. Conde, B. M. Popkin // Bull. World Health Organization. — 2004. — Vol. 82. — P. 940–946.

Management of Obesity in Adults: European Clinical Practice Guidelines [Text] / C. Tsigos, V. Hainer, A. Basdevant [et al.] // Междунар. эндокринол. журн. — 2010. — № 6 (30). — С. 126–143.

Наумов А. В. Распространенность и течение остеопороза у пациентов c соматическими заболеваниями [Текст] / А. В. Наумов // Междунар. эндокринол. журн. — 2010. — № 6 (30). — С. 107–115.

Cooper G. Epidemiology of osteoporotic fracture: looking to the future [Text] / G. Cooper // Reumatology. — 2005. — Vol. 4. — P. 36–40.

Подорога О. I. Новi пiдходи до лiкування остеопорозу (за матерiалами II Росiйського конгресу з остеопорозу) [Текст] / О. I. Подорога // Междун. эндокринол. ж. — 2006. — № 1 (3). — С. 100–110.

Cicuttini F. M. The association of obesity with osteoarthritis of the hand and knee in women: a twin study [Text] / F. M. Cicuttini, J. R. Baker, T. D. Spector / / J. Rheumatol. — 1996. — Vol. 23. — P. 1221–1226.

Marks R. Body mass indices in patients with disabling hip osteoarthritis [Text] / R. Marks, J. P. Allegrante // Arthritis Res. — 2002. — Vol. 4. —P. 112–116.

Tremollieres F. A. Vertebral postmenopausal bone loss is reduced in overweight women: a longitudinal study in 155 early postmenopausal women [Text] / F. A. Tremollieres, J. M. Pouilles, C. Ribot // J. Clin. Endocrinol. Metabol. — 1993. — Vol. 77. — P. 683–686.

Effects of weight and body mass index on bone mineral density in men and women: The framingham study [Text] / D. T. Felson, Y. Zhang, M. T. Hannan, J. J. Anderson // J. Bone Miner. Res. — 1993. — Vol. 8, N 8. — P. 567–573.

Reid I. R. Relationships among body mass, its components, and bone [Text] / I. R. Reid // Bone. — 2002. — Vol. 31. — P. 547–555.

Effect of weight loss on bone metabolism: comparison of vertical banded gastroplasty and medical intervention [Text] / E. Guney, G. Kisakol, G. Ozgen [et al.] // Obes. Surg. — 2003. — Vol. 13. — P. 383–388.

Estrogen Inhibits Bone Resorption by Directly Inducing Apoptosis of the Bone-resorbing Osteoclasts [Text] / T. Kameda, H. Mano, T. Yuasa [et al.] // J. exper. Med. — 1997. — Vol. 186. — P. 489–496.

Contribution of visceral fat mass to the insulin resistance of aging [Text] / W. T. Cefalu, Z. Q. Wang, S. Werbel [et al.] // Metabolism. — 1995. — Vol. 44, № 7. — P. 954–959.

Liver, muscle and adipose tissue insulin action in directly related to intrahepatie tryglyceride content in obese subjects [Text] / K. M. Korenblat, E. Fabbrini, B. S. Mohammed, S. Klein // Gastroenterology. — 2008. – Vol. 134. — P. 1369–1375.

Schindler A. E. Conversion od androstendione to estrone by human tissue [Text] / A. E. Schindler, A. Ebert, E. Friedrich // J. Clin. Endocrinol. Metabol. — 1972. — Vol. 35. — P. 627–630.

Leptin directly stimulates aromatase activity in human luteinized granulosa cells [Text] / J. Kitawaki, Y. Kusuki, H. Koshiba [et al.] // Mol. Hum. Reprod. — 1999. — Vol. 5–8. — P. 708–713.

Grodin J. Source of estrogen production in postmenopausal women [Text] / J. Grodin, P. Siiteri, P. MacDonald // J. Clin. Endocrinol. Metabol. — 1993. — Vol. 36. — P. 207–214.

Visceral fat accumulation in men is positively associated with insulin, glucose and C-peptide levels, but negatively with testosterone levels [Text] / J. C. Seidell, P. Bj¨orntorp, L. Sj¨ostr¨om [et al.] // Metabolism. — 1990. — Vol. 39. — P. 954–959.

Rosen S. J. Mechanismus of disease: is osteoporosis the obesity of bone? [Text] / S. J. Rosen, M. I. Bouzsein // Nat. clin. Pract. Reumotol. — 2006. — Vol. 2. — P. 35–43.

Ahima R. S. Adipose tissue as an endocrine organ. Trends [Text] / R. S. Ahima, J. S. Flier // Endocrinol. Metabol. — 2000. — Vol. 11. — P. 327–332.

Kershaw E. E. Adipose Tissue as an Endocrine Organ [Text] / E. E. Kershaw, J. S. Flier // J. Clin. Endocrinol. Metabol. — 2004. — Vol. 89, № 6. — P. 2548–2556.

Adipose tissue as an endocrine organ: from theory to practice [Текст] / M. H. Fonseca-Alaniz, J. Takada, M. I. Cardoso Alonso-Vale, F. B. Lima // J. Pediatr. (Rio J). — 2007. — Vol. 83 (Suppl. 5). — P. S192–203.

Ярмыш Н. В. Адипоцитокины в развитии инсулинорезистентности при ожирении [Tекст] / Н. В. Ярмыш, Н. А. Кравченко, Е. И. Войтенко // Пробл. ендокрин. патологiї. — 2010. — № 3. — С. 110–121.

Adipokines and insulin resistance [Text] / K. Rabe, V. Lehrke, K. G. Parhofer [et al.] // Molec. Med. — 2008. — Vol. 14, № 11–12. — P. 741–751.

Obesity is a associated with macrophage accumulationin adipose tissue [Text] / S. P. Weisberg, D. McCann, M. Desai [et al.] // J. clin invest. — 2003. — Vol. 112. — P. 1796–1808.

Permana P. A. Macrophage-secreted factors induce adipocyte inflamation and insulin resistance [Text] / P. A. Permana, C. Menge, P. D. Reaven // Biochem. Biophys. Res. Commun. — 2006. — Vol. 341. — P. 507–514.

Hajer G. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases [Текст] / G. Hajer, T.W. van Haeften, F. L. J. Visseren // Europ. Heart J. — 2008. — Vol. 29. — P. 2959–2971.

Friedman J. M. Leptin and the regulation of body weight in mammals [Text] / J. M. Friedman, J. L. Halaas // Nature. — 1998. — Vol. 395. — P. 763–770.

Терещенко И. В. Лептин и его роль в организме [Teкст] // Пробл. эндокринол. — 2001. — Т. 47, № 4. — С. 40–46.

Leptin: a link between obesity and osteoarthritis?. [Text] / B. Terlain, N. Presle, P. Pottie [et al.] // Bull Acad. Natl. Med. — 2006. — Vol. 190, № 7. —P. 1421–1435.

Effects of weight change on plasma leptin concentrations and energy expenditure [Text] / M. Rosenbaum, M. Nicolson, J. Hirsch [et al.]// J. Clin. Endocrinol. Metabol. — 1997. — Vol. 82. — P. 3647–3654.

The role of falling leptin levels in the neuroendocrineand metabolic adaptation to short-term starvationin healthy men. [Text] / J. L. Chan, K. Heist,A. M. DePaoli [et al.] // J. Clin. Invest. — 2003. —Vol. 111. — P. 1409–1421.

Hileman S. M. Leptin, Nutrition, and Reproduction:Timing Is Everything [Text] / S. M. Hileman,D. D. Pierroz, J. S. Flier // J. Clin. Endocrinol.Metabol. — 2000. — Vol. 85, № 2. — P. 804–807.

Чагай Н. Б. Лептин и репродуктивные органымишени (обзор литературы) [Teкст] / Чагай Н. Б.,Тумилович А. Г., Геворкян М. А. // Проблемы репродукции. — 2008. — № 3. — С. 29–34.

Positional cloning of the mouse obese gene and ithuman homologue [Text] / Y. Zhang, R. Proenca,M. Maffei [et al.] // Nature. — 1994. — Vol. 372. —P. 425–432.

Characterization and functional role of leptinreceptor in bovine adrenal medullary cells [Text]/ N. Yanagihara, K. Utsunomiya, T. B. Cheah [et al.]// Biochem. Pharmacol. — 2000. — Vol. 59, № 9. —P. 1141–1145.

Flier J. S. Leptin, nutrition, and the thyroid; the why, the wherefore, and the wiring [Text] / J. S. Flier, M. Harris, A. N. Hollenberg // J. Clin. Invest. — 2000. — Vol. 105. — P. 859–661.

Leptin is a metabolic signal to the reproductive system [Text] / I. A. Barash, C. C. Cheung, D. S. Weigle [et al.] // Endocrinology. — 1996. — Vol. 137. — P. 3144–3147.

Matarese G. Leptin in immunology [Text] / G. Matarese, S. Moschos, C. S. Mantzoros // J. Immunol. — 2005. — Vol. 174, № 6. — P. 3137–3142.

Towards a pro-inflammatory and immunomodulatory emerging role of leptin [Text] / M. Otero, R. Lago, R. Gomez [et al.] // Rheumatology (Oxford). — 2006. — Vol. 45, № 8. — P. 944–950.

Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis [Text] / S. Hashimoto, K. Takahashi, D. Amiel [et al.] // Arthritis Rheum. — 1998. — Vol. 41, № 7. — Р. 1266–1274.

Нейко Є. М. Сучаснi уявлення про патогенез деформуючого остеоартрозу [Teкст] / Є. М. Нейко, I.Ю. Головач // Український ревматологiчний журнал. — 2000. — № 1. — С. 9–12.

Evidence for a key role of leptin in osteoarthritis [Text] / H. Dumond, N. Presle, B. Terlain [et al.] // Arthritis Rheum. — 2003. — Vol. 48, № 11. — P. 3118–3129.

Human Articular Chondrocytes Express Functional Leptin Receptors [Text] / Y. Figenschau, G. Knutsen, S. Shahazeydi [et al.] // Biophys. Res. Commun. — 2001. — Vol. 287, № 1. — P. 190–197.

High-Dose Leptin Activates Human Leukocytes Via Receptor Expression on Monocytes [Text] / H. Zarkesh-Esfahani, G. Pockley, Russell A. Metcalfe [et al.] // J. Immunol. — 2001. — Vol. 167. — P. 4593–4599.

Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fi-broblasts [Text] / K. M. Tong, D. C. Shieh, C. P. Chen [et al.] // Cell Signal. — 2008. — Vol. 20, № 8. — P. 1478–1488.

Goldring M. B. The role of the chondrocyte in osteoarthritis [Text] / M. B. Goldring // Arthritis Rheum. — 2000. — Vol. 43, № 9. — P. 1916–1926.

Goldring M. B. The regulation of chondrocyte function by proinflammatory mediators: prostaglandins and nitric oxide [Text] / M. B. Goldring, F. Berenbaum // Clin. Orthop. Relat. Res. — 2004. — Vol. 427. — P. S37–46.

Leptin acts as a growth factor on the chondrocytes of skeletal growth centers [Text] / G. Maor, M. Rochwerger, Y. Segev, M. Phillip // J. Bone Miner. Res. — 2002. — Vol. 17, № 6. — P. 1034–1043.

Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: Impact on differentiation markers, apoptosis, and osteoclastic signaling [Text] / J. O. Gordeladze, C. A. Drevon, U. Syversen, J. E. Reseland // J. Cell Biochem. — 2002 — Vol. 85, № 4. — P. 825–836.

Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes [Text] / T. Thomas, F. Gori, S. Khosla [et al.] // Endocrinology. — 1999. — Vol. 140, № 4. — P. 1630–1638.

Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women [Text] / T. Thomas, B. Burguera, L. J. 3rdMelton [et al.] // Bone. — 2001. — Vol. 29,

№ 2. — P. 114–120.

Grimaud E. Recent advances in TGF-beta effects on chondrocyte metabolism. Potential therapeutic roles of TGF-beta in cartilage disorders [Text] / E. Grimaud, D. Heymann, F. T. R´edini // Cytokine Growth Factor Rev. — 2002. — Vol. 13, № 3. —

P. 241–257.

Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint [Text] / H. M. van Beuningen, P. M. van der Kraan, O. J. Arntz, W. B. van den Berg // Lab.

invest. — 1994. — Vol. 71, № 2. — P. 279–290.

Growth factor expression in the osteophytes of the human femoral head in osteoarthritis [Text] / M. Uchino, T. Izumi, T. Tominaga [et al.] // Clin Orthop Relat Res. — 2000. — Vol. 377. — P. 119–125.

Inhibition of Endogenous TGF-beta During Experimental Osteoarthritis Prevents Osteophyte Formation and Impairs Cartilage Repair [Text] / A. Scharstuhl, H. L. Glansbeek, H. M. van Beuningen [et al.] // J. Immunol. — 2002. — Vol. 169,

№ 1. — P. 507–514.

Stock S. M. Leptin levels vary significantly during the menstrual cycle, pregnancy, and in vitro fertilization treatment: possible relation to estradiol [Text] / S. M. Stock, E. M. Sande, K. A. Bremme / Fertil. Steril. — 1999. — Vol. 72, № 4. — P. 657–662.

Serum Leptin Levels in Normal Children: Relationship to Age, Gender, Body Mass Index, Pituitary-Gonadal Hormones, and Pubertal Stage [Text] / R. V. Garcia-Mayor, M. A. Andrade, M. Rios [et al.] // J. Clin. Endocrinol. Metabol. — 1997. — Vol. 82, № 9. — P. 2849–2855.

Leptin Inhibits Bone Formation through a Hypothalamic Relay: a central control of bone mass [Text] / P. Ducy, M. Amling, S. Takeda [et al.] // Cell. — 2000. — Vol. 92. — P. 73–78.

Khosla S. Editorial: Leptin — Central or Peripheral to the Regulation of Bone Metabolism? // Endocrinology. — 2002. — Vol. 143, № 11. — P. 4161–4164.

Karsenty G. Leptin controls bone formation through a hypothalamic relay [Text] // Recent Prog. Horm. Res. — 2001. — Vol. 56. — P. 401–415.

Leptin Reduces Ovariectomy-Induced Bone Loss in Rats [Text] / B. Burguera, L. C. Hofbauer, T. Thomas [et al.] // Endocrinology. — 2001. — Vol. 142. — P. 3546–3553

leptin regulates bone formation via the sympathetic nervous system / S. Takeda, F. Elefteriou, R. Levasseur [et al.] // Cell. — 2002. — Vol.111. — P. 305–317.

Bjorbaek C. Leptin Signaling in the Central Nervous System and the Periphery [Text] / C. Bjørbæk, B. B. Kahn // Rec. Progr. Horm. Res. — 2004. — Vol. 59. — P. 305–331.

Thomas T. The complex effects of leptin on bone metabolism through multiple pathways [Text] / T. Thomas // Curr. Opin. Pharmacol. — 2004. Vol. 4, № 3. — Р. 295–300.

The effect of leptin on bone: an evolving concept of action [Text] / V. Cirmanov´a, M. Bayer, L. St´arka, K. Zaj´ıckov´a // Physiol Res. 2008. — Vol. 57, Suppl. 1. — S. 143–151.

Relationship of Obesity with Osteoporosis [Text] / Lan-Juan Zhao, Yong-Jun Liu, Peng-Yuan Liu [et al.] / J. Clin. Endocrinol. Metabol. — 2006. — Vol. 92, № 5. — P. 1640–1646.

Mantzoros C. S. The Role of Leptin in Human Obesity and Disease: A Review of Current Evidence [Text] / C. S. Mantzoros // Ann. Intern. Med. — 1999. — Vol. 130, № 8. — P. 671–680.

Приступа Л. Н. Роль лептину в патогенезi остеопорозу при ожирiннi [Текст] / Л. Н. Приступа, О. I. Опiмах // Український ревматологiчний журнал. — 2010. — № 3 (41). — С. 64–67.

Нейко Є. М. Сучаснi уявлення про патогенез деформуючого остеоартрозу [Текст] / Є. М. Нейко, I.Ю. Головач // Український ревматологiчний журнал. — 2000. — № 1. — С. 9–12.

Kos K. Adipokines: emerging therapeutic targets [Text] / K. Kos, J. P. Wilding // Curr. Opin. Investig. Drugs. — 2009. — Vol. 10, № 10. — P. 1061–1068.

Leptin-Replacement Therapy for Lipodystrophy [Text] / E. A. Oral, V. Simha, E. Ruiz [et al.] // N. Engl. J. Med. — 2002. — Vol. 346. — P. 570–578.

Leptin receptor action and mechanisms of leptin resistance [Text] / Н. M¨unzberg, М. Bj¨ornholm, S. H. Bates, M. G. Myers // Cell Mol. Life Sci. — 2005. — Vol. 62, № 6. — P. 642–652.

Myers M. G. Mechanisms of leptin action and leptin resistance [Text] / M. G. Myers, M. A. Cowley, H. M¨unzberg // Annu. Rev. Physiol. — 2008. — Vol. 70. — P. 537–556.

Kalra S. Central leptin insufficiency syndrome: an interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions [Text] / S. Karla // Peptides. — 2008. — Vol. 29, № 1. — Р. 127–138.

Glucocorticoids as counterregulatory hormones of leptin: toward an understanding of leptin resistance [Text] / K. E. Zakrzewska, I. Cusin, A. Sainsbury [et al.] // Diabetes. — 1997. — Vol. 46, № 4. — P. 717–719.

Solano J. M. Glucocorticoids reverse leptin effects on food intake and body fat in mice without increasing NPY mRNA [Text] / J. M. Solano, L. Jacobson // AJP-1999. — Vol. 277. — P. 708–716.

Barker D. J. P. Review In utero programming of chronic disease [Text] / D. J. P. Barker // Clin. Scien. — 1998. — Vol. 95. — P. 115–128.

Fetal origins of adult disease: strength of effects and biological basis [Text] / D. J. Barker, J. G. Eriksson, T. Forsen, C. Osmond // Int. J. Epidemiol. — 2002. — Vol. 31. — P. 1235–1239.

Резнiков О. Г. Програмування нащадкової функцiональної патологiї в ранньому онтогенезi [Текст] / О. Г. Резнiков // Клiнич. та екперим. патологiя. — 2004. — Т. III, № 2, 4. 1. — С. 10–12.

Seckl J. R. Glucocorticoid programming of the fetus: adult phenotypes and molecular mechanisms [Text] / J. R. Seckl // Molec. Cell. Endocrinol. — 2001. — Vol. 185, № 1–2. — P. 61–71.

Prenatal stress induces intrauterine growth restriction and programmes the glucose intolerance and feeding behavior disturbances in the aged rat [Text] / J. F. Lesage, F. Del-Favero, M. Leonhardt [et al.] // J. Endocrinol. — 2004. — Vol. 181. — P. 291–296.

Нагаева Е. В. «Внутриутробное программирование» гормонально-метаболических процессов и синдром задержки внутриутробного развития [Текст] / Е. В. Нагаева, Т.Ю. Ширяева // Пробл. ендокринол. — 2010. — № 6. — С. 32–40.

Placental leptin: an important new growth factor in intrauterine and neonatal development? [Text] / S. G. Hassink, E. de Lancey, D. V. Sheslow // Pediatrics. — 1997. — Vol. 100. — P. 117–123.

Prenatal leptin production: evidence that fetal adipose tissue produces leptin [Text] / J. Lepercq, J. C. Challier, M. Guerre-Millo // J. Clin. Endocrinol. Metabol. — 2001. — Vol. 86. — P. 2409–2413.

Placental leptin correlates with intrauterine fetal growth and development [Text] / X. Ben, Y. Qin, S. Wu [et al.] // Chin. Med. J. (Engl). — 2001. — Vol. 114. — P. 636–639.

Ontogeny of leptin in human fetuses and newborns: effect of intrauterine growth retardation on serum leptin concentrations [Text] / D. Jaquet, J. Leger, C. Levy-Marchal [et al.] // J. Clin. Endocrinol. Metab. — 1998. — Vol. 83. — P. 1243–1246.

Umbilical cord leptin predicts neonatal bone mass [Text] / M. K. Javaid, K. M. Godfrey, P. Taylor [et al.] // Calcif. Tissue Int. — 2005. — Vol. 76. — P. 341–347.

Neonatal leptin levels are strongly associated with female gender, birth length, IGF-I levels and formula feeding [Text] / E. Petridou, Ch. S. Mantzoros, M. Belechri [et al.] // Clin. Endocrinol. — 2005. — Vol. 62. — P. 366–371.

Determinants of Early Life Leptin Levels and Later Life Degenerative Outcomes [Text] / D.-M. Alexe, G. Syridou, E. Th. Petridou // Clin. Med. Res. — Vol. 4, № 4. — P. 326–335.

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Published

2011-06-02

How to Cite

Sergiyenko, L. Y. (2011). OBESITY AND OSTEOPATHY - EMBRYONIC DETERMINISTIC LEPTIN-ASSOCIATED DISEASES (Literature review, own data and hypotheses). Problems of Endocrine Pathology, 36(2), 88-98. https://doi.org/10.21856/j-PEP.2011.2.13

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