THE ROLE OF LEPTIN AND ADIPONEKTIN IN FORMATION INSULIN RESISTANCE IN CHILDREN OF PUBERTIC AGE, WHO SUFFER FROM OBESITY

Authors

  • Shlyakhova N. V. SI "Institute of Health of Children and Adolescents of the National Academy of Medical Sciences of Ukraine", Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2011.4.08

Keywords:

leptin, adiponectin, insulin resistance, obesity, children

Abstract

Serum leptin and adiponectin concentrations in obese children were determined (65 children with insulin resistance and 55 children without its symptoms), as well as 25 of their peers with normal weight. It is established that obesity in children is accompanied by increased production of leptin and reduced - adiponectin, the changes of which are more pronounced in children with insulin resistance. Level leptin is associated with body mass index regardless of the presence of insulin resistance, and the content adiponectin is associated with body mass index only in children with insulin resistance.

References

Biro, F. M. Childhood obesity and adult morbidities [Text] / F. M. Biro, M. Wien // Am. J. Clin. Nutr. — 2010. — Vol. 91. — P. 1499–1505.

Weiss, R. Metabolic complications of childhood obesity: identifying and mitigating the risk [Text] / R. Weiss, F. R. Kaufman // Diabetes Care. — 2008. — Vol. 31. — P. 310–316.

Predicting overweight and obesity in adulthood from body mass index values in childhood and adolescence [Text] / S. S. Guo, W. Wu, W. C. Chumlea, A. F. Roche // Am. J. Clin. Nutr. — 2002. — Vol. 76. — P. 653–658.

Are obesity-related metabolic risk factors modulated by the degree of insulin resistance in adolescents? [Text] / F. Bacha, R. Saad, N. Gungor, S. A. Arslanian // Diabetes Care. — 2006. — Vol. 29. — P. 1599–1604.

Increased insulin secretion in puberty: a compensatory response to reductions in insulin sensitivity [Text] / S. Caprio, G. Plewe, M. P. Diamond [et al.] // J. Pediatr. — 1989. — Vol. 114. — P. 963–967.

Bajaj, M. Metabolic and molecular basis of insulin resistance [Text] / M. Bajaj, R. A. Defronzo // J. Nucl. Cardiol. — 2003. — Vol. 10. — P. 311– 323.

Biddinger, S. B. From mice to men: insights into the insulin resistance syndromes [Text] / S. B. Biddinger, C. R. Kahn // Ann. Rev. Physiol. — 2006. — Vol. 68. — P. 123–158.

Esteve, E. Adipocytokines and Insulin Resistance [Text] / E. Esteve, W. Ricart, J. M. Fernandez-Real // Diabetes Care. — 2009. — Vol. 32. — P. 362–367.

Adipokines and Insulin Resistance [Text] / K. Rabe, M. Lehrke, K. G. Parhofer, U. C. Broedl // Mol. Med. — 2008. — Vol. 14. — P. 741–751.

Plasma leptin concentrations and obesity in relation to insulin resistance syndrome components among school children in Taiwan — the Taipei Children Heart Study [Text] / N. F. Chu, D. J. Wang, S. M. Shieh, E. B. Rimm // Intern. J. Obesit. Rel. Metabol. Disord. — 2000. Vol. 24. — P. 1265–1271.

Roles for leptin receptor/STAT3-dependent and - independent signals in the regulation of glucose homeostasis [Text] / S. H. Bates, R. N. Kulkarni, M. Seifert, M. G. Jr. Myers // Cell. Metabol. — 2005. — Vol. 1. — P. 169–178.

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism [Text] / B. B. Kahn, T. Alquier, D. Carling, D. G. Hardie // Cell. Metabol. — 2005. — Vol. 1. — P. 15–25.

Leptin stimulates fattyacid oxidation by activating AMP-activated protein kinase [Text] / Y. Minokoshi, Y. B. Kim, O. D. Peroni [et al.] // Nature. — 2002. — Vol. 415. — P. 339–43.

Niswender, K. D. Obesity and the beta cell: lessons from leptin [Text] / K. D. Niswender, M. A. Magnuson // J. Clin. Invest. — 2007. — Vol. 117. — P. 2753–27566.

Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice [Text] / T. Morioka, E. Asilmaz, J. Hu [et al.] // J. Clin. Invest. — 2007. — Vol. 117. — P. 2860– 2868.

Kieffer, T. J. The adipoinsular axis: effects of leptin on pancreatic beta-cells [Text] / T. J. Kieffer, J. F. Habener // Am. J. Physiol. Endocrinol. Metabol. — 2000. — Vol. 278. — P. 1–14.

Unger, R. H. Lipotoxic diseases [Text] / R. H. Unger // Ann. Rev. Med. — 2002. — Vol. 53. P. 319–336.

Berg, A. H. Adiponectin: an adipokine regulating glucose and lipid metabolism [Text] / A. H. Berg, T. P. Combs, P. E. Scherer // Trends. Endocrinol. Metabol. — 2002. — Vol. 13. — P. 84–89.

Adiponectin in childhood and adolescent obesity and its association with inflammatory markers and components of the metabolic syndrome [Text] / J. C. Winer, T. L. Zern, S. E. Taksali [et al.] // J. Clin. Endocrinol. Metabol. — 2006. — Vol. 91. — P. 4415–4423.

Hypoadiponectinemia and proinflammatory state: two sides of the same coin? results from the Cooperative Health Research in the Region of Augsburg Survey 4 (KORA S4) [Text] / C. Herder, H. Hauner, B. Haastert [et al.] // Diabetes Care. — 2006. — Vol. 29. — P. 1626–1631.

Adiponectin: more than just another fat cell hormone? [Text] / M. Chandran, S. A. Phillips, T. Ciaraldi, R. R. Henry // Diabetes Care. — 2003. — Vol. 26. — P. 2442–2450.

Adiponectin and protection against type 2 diabetes mellitus [Text] / J. Spranger, A. Kroke, M. Möhlig [et al.] // Lancet. — 2003. — Vol. 361. — P. 226– 228.

Adiponectin and development of type 2 diabetes in the Pima Indian population [Text] / R. S. Lindsay, T. Funahashi, R. L. Hanson [et al.] // Lancet. — 2002. — Vol. 360. — P. 57–58.

Протоколи надання медичної допомоги дiтям за спецiальнiстю «Дитяча ендокринологiя» [Текст] / под ред. Н. Б. Зеленської // МОЗ України. — К., 2006. — 94 с.

Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man [Text] / D. R. Matthews, J. P. Hosker, A. S. Rudenski [et al.] // Diabetologia. — 1985. — Vol. 28. — P. 412–419.

Дислипидемии при эндокринных заболевания: монография [Текст] / Н. А. Кравчун, Ю. И. Караченцев, О. А. Гончарова [и др.]. — Х.: Прапор, 2008. — 224 с.

Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone [Text] / W. F. Blum, P. Englaro, S. Hanitsch [et al.] // J. Clin. Endocrinol. Metabol. — 1997. — Vol. 82. — P. 2904–2910.

ponectin levels develop during the progression of puberty and are related to serum androgen levels [Text] / A. Bottner, J. Kratzsch, G. Müller [et al.] // J. Clin. Endocrinol. Metabol. — 2004. — Vol. 89. — P. 4053–4061.

Шляхова, Н. В. Продукцiя адипонектину та лептину у дiтей пубертатного вiку з нейроендокринним ожирiнням [Текст] / Н. В. Шляхова, О. А. Будрейко, Д. А. Кашкалда // Укр. мед. альманах. — 2011. — Т. 14, № 4. — С. 121–124.

Adiponectin, IL-10 and metabolic syndrome in obese children and adolescents [Text] / V. Calcaterra, M. De Amici, C. Klersy [et al.] // Acta Biomed. — 2009. — Vol. 80. — P. 117–123.

Low-grade inflammation, obesity, and insulin resistance in adolescents [Text] / C. Herder, S. Schneitler, W. Rathmann [et al.] // J. Clin. Endocrinol. Metabol. — 2007. — Vol. 92. — P. 4569–4574.

Leptin concentrations are associated with higher proinsulin and insulin concentrations but a lower proinsulin/insulin ratio in non-diabetic subjects [Text] / S. M. Haffner, H. Miettinen, L. Mykkanen, M. P. Stern // Int. J. Obes. — 1998. — Vol. 22. — P. 899–905.

Stefan, N. Adiponectin: its role in metabolism and beyond [Text] / N. Stefan, M. Stumvoll // Horm. Metabol. Res. — 2002. — Vol. 34. — P. 469–474.

Szanto, I. Selective interaction between leptin and insulin signaling pathways in a hepatic cell line [Text] / I. Szanto, C. R. Kahn // Proc. Natl. Acad. Sci., USA. — 2000. — Vol. 97. — P. 2355–2360.

Recent advances in the relationship between obesity, inflammation, and insulin resistance [Text] / J.-P. Bastard, M. Maachi, C. Lagathu [et al.] // Europ. Cytokine Netw. — 2006. — Vol. 17, № 1. — P. 4–12.

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Published

2011-12-29

How to Cite

Shlyakhova, N. V. (2011). THE ROLE OF LEPTIN AND ADIPONEKTIN IN FORMATION INSULIN RESISTANCE IN CHILDREN OF PUBERTIC AGE, WHO SUFFER FROM OBESITY. Problems of Endocrine Pathology, 38(4), 52-59. https://doi.org/10.21856/j-PEP.2011.4.08

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Section

CLINICAL ENDOCRINOLOGY