IRON METABOLISM, ERYTHROPOIESIS AND IMMUNE INFLAMMATION IN ANEMIC PATIENTS WITH CHRONIC HEART FAILURE IN THE PRESENCE OF DIABETIC NEPHROPATHY

Authors

  • Ryndina N. G. Kharkiv National Medical University, Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2016.2.06

Keywords:

chronic heart failure, anemia, diabetic nephropathy, iron metabolism, immune inflamation

Abstract

The development of anemia in patients with chronic heart failure by the presence of diabetic
nephropathy is characterized by erythropoietyc activity fall due to the low level of erythropoietin
and functional iron deficiency, as a result of influence of pro-inflammatory cytokine level on hepcidin
activity, resulting in the disruption of the functional iron fund, deposited block of iron. The presence
of microalbuminaemia can be considered as a factor in formation of anemic syndrome due to loss of
erythropoietin, transferrin, soluble transferring receptor as a part of protein’s pool in patients with
chronic heart failure and diabetic nephropathy. The presence of anemia in patients with chronic heart
failure and diabetic nephropathy is associated with inadequate low central regulator of erythropoiesis
level in response to low hemoglobin concentrations on background of moderate decrease in glomerular
filtration rate.

References

Inzucchi SE, Bergenstal RM, et al. Diabetologia 2012; 55(6):1577-1596.

Graham UM, Magee GM, Hunter SJ, et al. Ulster Med J 2010; 79(2):57-61.

McClellan W, Aronoff S, Bolton W, et al. Curr Med Res Opin 2004; 20:1501-1510.

Astor B, Muntner P, Levin A, et al. Arch Intern Med 2002; 162:1401-1408.

Sarnak M, Tighiouart H, Manjunath G, et al. J Am Coll Cardiol 2002; 40:27-33.

Lipsic E, van der Meer P. Eur J Heart Failure 2010; 12:104-105.

Silverberg DS, Steinbruch D, Schwartz Y. Int Urol Nephrol 2006; 38:295-310.

Silverberg D, Iaina A, Wexler D, et al. Hypertension 2011; 57:381-382.

Thomas M, MacIsaac R, Tsalamandris C, et al. Diabetes Care 2003; 26:1164-1169.

Vlagopoulos P, Tighiouart H, Weiner D, et al. J Am Soc Nephrol 2005; 16:3403-3410.

Scrutinio D, Passantino A, Santoro D, et al. Eur J Heart Failure 2011; 13:61-67.

von Haehling S, Anker SD. Contrib Nephrol 2011; 171:266-273.

Opasich C, Cazzola M, Scelsi L. Eur Heart J. 2005; 26:2232-2237.

Anker SD, McMurray JJ, Ponikowski P. Eur J Heart Failure 2009; 11:1084-1091.

McMurray J, Adamopoulos S, Anker SD, et al. Eur J Heart Failure 2012; 14:803-869.

Kidney Disease: Improving Global Outcomes (KDIGO) Anemia Work Group. Kidney Inter 2012; 2:279-335.

Mazur LI, Makoveckaja GA, Balashov EA. Uspehi Sovremennogo Estestvoznanija 2009; 11:85-86.

Downloads

Published

2016-06-08

How to Cite

Ryndina, N. G. (2016). IRON METABOLISM, ERYTHROPOIESIS AND IMMUNE INFLAMMATION IN ANEMIC PATIENTS WITH CHRONIC HEART FAILURE IN THE PRESENCE OF DIABETIC NEPHROPATHY. Problems of Endocrine Pathology, 56(2), 42-46. https://doi.org/10.21856/j-PEP.2016.2.06

Issue

Section

CLINICAL ENDOCRINOLOGY