• Antipova R. B. Kharkiv National Pedagogical University. GS Skovoroda, Kharkiv, Ukraine
  • Komisova T. E. Kharkiv National Pedagogical University. GS Skovoroda, Kharkiv, Ukraine
  • Velichko N. F. SI «V. Danilevsky Institute for Endocrine Pathology Problems National Academy of Medical Sciences of Ukraine», Kharkiv, Ukraine
  • Sak A. Ye. Kharkiv State Academy оf Physical Culture, Kharkiv, Ukraine




male hypofertility, sunflower oil, spermatogenesis, sex hormones


Introduction. Today, the search for reasons to reduce male fertility remains an urgent task. One of them may be an imbalance in nutrition for nutrients such as polyunsaturated fatty acids (omega-3 and omega-6), which is the main component of sunflower oil. The interaction of omega-3 and omega-6 fatty acids and their lipid mediators is a complex and still not fully understood process. However, the relationship between omega-6 and omega-3 acids during perinatal development is known to affect metabolic parameters in adulthood, especially in males. Sunflower oil is unbalanced in terms of omega-3 and omega-6 fatty acids. Moreover, the content of omega-6 in the oil significantly exceeds the concentration of omega-3. It should be noted that the lack of omega-3 in the body leads to roughening of the membranes of all cells, including sperm. This negatively affects the fertilizing ability of gametes, and with successful fertilization — on the viability of embryos. Therefore, the benefits and safety of excessive and chronic consumption of sunflower oil, especially for males, is open. The aim of the study was to establish the effects of chronic and excessive consumption of refined sunflower oil for hormonal status and reproductive function in adult male rats. Results. In experimental 7-month-old male rats, supplementation of the standard diet with refined sunflower oil at a dose of 3 g/kg body weight (excess fat by 1.5 times) for 75 days led to androgen deficiency (decreased free and total testosterone), hyperestrogenism, disorders physiological ratio of sex hormones. Hormonal disorders were accompanied by defects in spermatogenesis: a decrease in the total concentration of gametes, morphologically normal forms, an increase in pathological forms.


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How to Cite

Antipova, R. B., Komisova, T. E., Velichko, N. F., & Sak, A. Y. (2020). HORMONAL AND REPRODUCTIVE DISORDERS IN MALE RATS DUE TO EXCESSIVE CONSUMPTION OF REFINED SUNFLOWER OIL. Problems of Endocrine Pathology, 73(3), 98-103. https://doi.org/10.21856/j-PEP.2020.3.12