• Antipova R. B. Kharkiv National Pedagogical University. GS Skovoroda, Kharkiv, Ukraine
  • Komisova T. E. Kharkiv National Pedagogical University. GS Skovoroda, Kharkiv, Ukraine
  • Velichko N. F. SI «V. Danilevsky Institute for Endocrine Pathology Problems National Academy of Medical Sciences of Ukraine», Kharkiv, Ukraine
  • Sak A. Ye. Kharkiv State Academy оf Physical Culture, Kharkiv, Ukraine




male hypofertility, sunflower oil, spermatogenesis, sex hormones


Introduction. Today, the search for reasons to reduce male fertility remains an urgent task. One of them may be an imbalance in nutrition for nutrients such as polyunsaturated fatty acids (omega-3 and omega-6), which is the main component of sunflower oil. The interaction of omega-3 and omega-6 fatty acids and their lipid mediators is a complex and still not fully understood process. However, the relationship between omega-6 and omega-3 acids during perinatal development is known to affect metabolic parameters in adulthood, especially in males. Sunflower oil is unbalanced in terms of omega-3 and omega-6 fatty acids. Moreover, the content of omega-6 in the oil significantly exceeds the concentration of omega-3. It should be noted that the lack of omega-3 in the body leads to roughening of the membranes of all cells, including sperm. This negatively affects the fertilizing ability of gametes, and with successful fertilization — on the viability of embryos. Therefore, the benefits and safety of excessive and chronic consumption of sunflower oil, especially for males, is open. The aim of the study was to establish the effects of chronic and excessive consumption of refined sunflower oil for hormonal status and reproductive function in adult male rats. Results. In experimental 7-month-old male rats, supplementation of the standard diet with refined sunflower oil at a dose of 3 g/kg body weight (excess fat by 1.5 times) for 75 days led to androgen deficiency (decreased free and total testosterone), hyperestrogenism, disorders physiological ratio of sex hormones. Hormonal disorders were accompanied by defects in spermatogenesis: a decrease in the total concentration of gametes, morphologically normal forms, an increase in pathological forms.


Khlyakina OV. Bull TSU 2011; 16(1): 356-359.

Obukhova LA. Vegetable oils in nutrition. Comparative analysis, available at : https://www.argo-shop.com.ua/

Pilipenko TV, Astafyeva VV, Stepanova NYu. News of St. Petersburg State Agrarian University 2015; 3(56): 90-97.

Norms of physiological requirements for energy and nutrients for various groups of the population of the Russian Federation, Moskva : Federal center for sanitary inspection of the ministry of health of Russia, 2008: 43 р.

Zanini SF, Torres CA, Bragagnolo N, et al. Arch Tierernahr 2003; 57(6): 429-442. https://doi.org/10.1080/0003942032000161072.

Innes JK, Calder PC. Prostaglandins Leukot Essent Fatty Acids 2 018; 3 2:41-48. https://doi.org/10.1016/j.plefa.2018.03.004.

Korotkova M, Gabrielsson BG, Holmдng A, et al. Am J Physiol Regul Integr Comp Physiol 2005; 288(3): 575- 579. https://doi.org/10.1152/ajpregu.00342.2004.

Traber MG, Buettner GR, Bruno RS. Redox Biol 2019; 21: 101091. https://doi.org/10.1016/j.redox.2018.101091.

Loo TM, et al. Cancer Discov 2017; 7: 522-538. https://doi.org/10.1158/2159-8290.CD-16-0932.

Kaliannan K. Commun Biol 2 019; 2 (1): Art 276. https://doi.org/10.1038/s42003-019-0521-4.

Araya J. Cagalj AI. Arch Latinoam Nutr 1993; 43(2): 123-131.

Esmaeili V, Shahverdi AH, Moghadasian MH, et al. Andrology 2015; 3(3): 450-461. https://doi.org/10.1111/andr.12024.

Makarova SG, Vishneva EA. Pediatric Pharmacol 2013; 10(4): 80-88.

European convention for the protection of vertebrate animals used for experimental and other scientific purposes. European Treaty Series, Strasbourg, 1986; 123: 1-11.

Glans S. Mediko-biologicheskaja statistika, Moskva, 1998: 459 p.

Mukherjee R, Choi JW, Choi DK. Cell Physiol Biochem 2012; 29(3-4): 617-634. https://doi.org/10.1159/000338515.

Martнnez-Soto JC, Landeras J, Gadea J. Andrology 2013; 1(3): 365-375. https://doi.org/10.1111/j.2047-2927.2012.00040.x.

Behre HM, Bergmann M, Simoni M, Tьttelmann F. Primary testicular failure, available at : http://www.endotext.org.

Schisterman EF. Andrology 2 014; 2 (3): 4 08-415. https://doi.org/10.1111/j.2047-2927.2014.00198.x.

Safarinejad MR. Clin Nutr 2 010; 2 9(1): 1 00-105. https://doi.org/10.1016/j.clnu.2009.07.008.




How to Cite

Antipova, R. B., Komisova, T. E., Velichko, N. F., & Sak, A. Y. (2021). HORMONAL AND REPRODUCTIVE DISORDERS IN MALE RATS DUE TO EXCESSIVE CONSUMPTION OF REFINED SUNFLOWER OIL. Problems of Endocrine Pathology, 73(3), 98-103. https://doi.org/10.21856/j-PEP.2020.3.12