EFFECT OF OMEGA-3 POLYUNSATURATED FATTY ACIDS ON CLASSIC AND NOVEL CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS (review and our own results)

Authors

DOI:

https://doi.org/10.21856/j-PEP.2012.4.19

Keywords:

type 2 diabetes mellitus, omega-3 polyunsaturated fatty acids, cardiovascular diseases, type 2 diabetes mellitus, omega-3 polyunsaturated fatty acids, cardiovascular diseases

Abstract

Review is devoted to the metabolic impact and realization mechanisms of the effect of short and long-time omega-3 polyunsaturated fatty acid supplementation on classic and novel cardiovascular risk parameters, also in type 2 diabetes mellitus.

References

Grundy, S. M. Metabolic syndrome, connecting and reconciling cardiovascular and diabetes worlds [Text] / S. M. Grundy // J. Am. Coll. Cardiol. — 2006. — Vol. 47. — P. 1093–1100.

Krauss, R. M. Lipids and lipoproteins in patients with type 2 diabetes [Text] / R. M. Krauss // Diabetes Care. — 2004. — Vol. 27. — P. 1496–1504.

Contribution of elevated free fatty acid levels to the lack of glucose effectiveness in type 2 diabetes [Text] / M. Hawkins, J. Tonelli, P. Kishore [et al.] // Diabetes. — 2003. — Vol. 52. — P. 2748–2758.

Stocker, R. Role of oxidative modifications in atherosclerosis [Text] / R. Stocker, J. F. Keaney Jr. // Physiol. Rev. — 2004. — Vol. 84. — P. 1381–1478.

Simopoulos, A. P. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases [Text] / A. P. Simopoulos // Exp. Biol. Med. — 2008. — Vol. 233. — P. 674–688.

Wardhana. The role of omega-3 fatty acids contained in olive oil on chronic inflammation [Text] / Wardhana, E. E. Surachmanto, E. A. Datau // Acta Med. Indones-Indones J. Intern. Med. — 2011. — Vol. 43, № 2. — P. 138–143.

Polyunsaturated fatty acids and their effects on cardiovascular disease [Text] / B. P. Ander, C. M. C. Dupasquier, M. A. Prociuk, G. N. Pierce // Exp. Clin. Cardiol. — 2003. — Vol. 8, № 4. — P. 164–172.

Diet and insulin resistance: A review and Asian Indian perspective [Text] / S. Isharwal, A. Misra, J. S. Wasir, P. Nigam // Indian J. Med. Res. — 2009. — Vol. 129. — P. 485–499.

Mediterranean-inspired diet lowers the ratio of serum phospholipid n-6 to n-3 fatty acids, the number of leukocytes and platelets, and vascular endothelial growth factor in healthy subjects [Text] / A. Ambring, M. Johansson, M. Axelsen [et al.]

// Am. J. Clin. Nutr. — 2006. — Vol. 83. — P. 575–581.

Cardiovascular protective effects of n-3 polyunsaturated fatty acids with special emphasis on docosahexaenoic acid [Text] / M. Hirafuji, T. Machida, N. Hamaue, M. Minami // J. Pharmacol. Sci. — 2003. — Vol. 92. — P. 308–316.

Calder, P. C. n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored [Text] / P. C. Calder // Clin. Science. — 2004. — Vol. 107. — P. 1–11.

Das, U. N. Essential fatty acids — a review [Text] / U. N. Das // Curr. Pharm. Biotechnol. — 2006. — Vol. 7, № 6. — P. 467–482.

Simopoulos, A. P. Omega-3 fatty acids in inflammation and autoimmune diseases [Text] / A. P. Simopoulos // J. Am. Col. Nutr. — 2002. — Vol. 6. — P. 495–505.

Anderson, B. M. Are all n-3 polyunsaturated fatty acids created equal? [Text] / B. M. Anderson, D.W.L. Ma // Lipids in Health and Disease. — 2009. — Vol. 8 (33).

Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega- 3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing [Text] / C. N. Serhan, C. B. Clish, J. Brannon [et al.] // J. Exp. Med. — 2000. — Vol. 192, № 8. — P. 1197–1204.

Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals [Text] / C. N. Serhan, S. Hong, K. Gronert [et al.] // J. Exp. Med. — 2002. —Vol. 196, № 8. — P. 1025–1037.

Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression [Text] / V. L. Marcheselli, Hong. S, W. J. Lukiw [et al.] // J. Biol. Chem. — 2003. — Vol. 278, № 44. — P. 43807–43817.

Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress [Text] / P. K. Mukherjee, V. L. Marcheselli, C. N. Serhan, N. G. Bazan // Proc. Natl. Acad. Sci. USA. — 2004. — Vol. 101, № 22. — P. 8491–8496.

Das, U. N. Essential fatty acids: biochemistry, physiology and pathology [Text] / U. N. Das // Biotechnol. J. — 2006. — Vol. 1, № 4. — P. 420–439.

Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1 [Text] / M. Arita, F. Bianchini, J. Aliberti [et al.] // J. Exp. Med. — 2005. — Vol. 201, № 5. — P. 713–722.

A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease [Text] / W. J. Lukiw, J. G. Cui, V. L. Marcheselli [et al.] // J. Clin. Invest. — 2005. — Vol. 115, № 10. — P. 2774–2783.

n-3 Fatty acids and cardiovascular disease risk factors among the Inuit of Nunavik [Text] / E. Dewailly,C. Blanchet, S. Lemieux [et al.] // Am. J. Clin. Nutr. — 2001. — Vol. 74. — P. 464–473.

De Lorgeril, M. Modified Cretan Mediterranean diet in the prevention of coronary heart disease and cancer. An update [Text] / M. de Lorgeril, P. Salen // World Rev. Nutr. Diet — 2007. — Vol. 97. — P. 1–32.

Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese. The Japan Public Health Center-Based (JPHC) Study Cohort I. [Text] / H. Iso, M. Kobayashi, J. Ishihara [et al.]; JPHC Study Group // Circulation — 2006. — Vol. 113. —

P. 195–202.

Carpentier, Y. A. n–3 Fatty acids and the metabolic syndrome [Text] / Y. A. Carpentier, L. Portois, W. J. Malaisse // Am. J. Clin. Nutr. — 2006. — Vol. 83, suppl. — P. 1499S–1504S.

n–3 Fatty acids and cardiovascular outcomes in patients with dysglycemia [Text] / The ORIGIN Trial Investigators // N. Engl. J. Med. — 2012. — Vol. 367. — P. 309–318.

Randomized controlled trial of the effect of n-3 fatty acid supplementation on the metabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesity [Text] / D. C. Chan,G. F. Watts, T. A. Mori [et al.] // Am. J. Clin. Nutr. — 2003. — Vol. 77. — P. 300–307.

The effect of Omega-3 fatty acids on serum paraoxonase activity, vitamins A, E, and C in type 2 diabetic patients [Text] / A. Kouchak, M. Djalali, M. Eshraghian [et al.] // J. Res. Med. Sci. — 2011. — Vol. 16, № 7. — P. 878–884.

Deckelbaum, R. J. N-3 fatty acids and gene expression [Text] / R. J. Deckelbaum, T. S. Worgall, T. Seo // Am. J. Clin. Nutr. — 2006. — Vol. 83, suppl. — P. 1520S-1525S.

Down-regulation in muscle and liver lipogenic genes: EPA ethyl ester treatment in lean and overweight (high-fat-fed) rats [Text] / N. PerezEcharri, P. Perez-Matute, B. Marcos-Gomez [et al.] // J. Nutr. Biochem. — 2009. — Vol. 20. — P. 705–714.

Guan, Y. Peroxisome proliferator-activated receptors (PPARs): Novel therapeutic targets in renal disease [Text] / Y. Guan, M. D. Breyer // Kidney Int. — 2001. –Vol. 60. — P. 14–30.

Staels, B. Therapeutic roles of peroxisome proliferator-activated receptor agonists [Text] / B. Staels, J. C. Fruchart // Diabetes. — 2005. — Vol. 54. — P. 2460–2470.

Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay [Text] / G. Krey, O. Braissant, F. L’Horset [et al.] // Mol. Endocrinol. — 1997. —

Vol. 11. — P. 779–791.

Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPAR alpha [Text] / S. Sethi, O. Ziouzenkova, H. Ni [et al.] // Blood. — 2002. — Vol. 100. — P. 1340–1346.

Eicosapentaenoic acid, but not oleic acid, stimulates beta-oxidation in adipocytes [Text] / W. Guo, W. Xie, T. Lei, J. A. Hamilton // Lipids. — 2005. — Vol. 40. — P. 815–821.

Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat [Text] / P. Flachs, O. Horakova, P. Brauner [et al.] // Diabetologia. — 2005. — Vol. 48. — P. 2365–2375.

N-3 long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity? [Text] / J. Delarue, C. LeFoll, C. Corporeau [et al.] // Reprod. Nutr. Dev. — 2004. — Vol. 44. — P. 289–299.

Regulation of glucose transport and transporter 4 (GLUT-4) in muscle and adipocytes of sucrose-fed rats: effects of N-3 poly- and monounsaturated fatty acids [Text] / Peyron-Cas E., Fluteau-Nadler S., Kabir M. [et al.] // Horm. Metab. Res. — 2002. — Vol. 34. — P. 360–366.

De Santa Olalla, L. M. N-3 fatty acids in glucose metabolism and insulin sensitivity [Text] / L. M. de Santa Olalla, F. J. S. Muniz, M. P. Vaquero // Nutr. Hosp. — 2009. — Vol. 24. — P. 113–127.

Sweeney, B. Fatty acid modulation of phagocyte apoptosis: a potentially novel mechanism of regulating the innate inflammatory response [Text] / B. Sweeney, P. Pury, D. Reen // Immunology. — 2001. — Vol. 104, suppl. 1. — P. 49.

Comparison of cytokine modulation by natural peroxisome proliferator-activated receptor γ ligands with synthetic ligans in intestinal-like-caco-2 cells and human dentritic cells-potential for dietary modulation of peroxisome proliferator-activated receptor γ in intestinal inflammation [Text] / R. M. Letellier, M. Butler, P. Dechelotte [et al.] // Am. J. Clin. Nutr. — 2008. — Vol. 87. — P. 939–948.

Kalupahana, N. S. (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights [Text] / N. S. Kalupahana, K. J. Claycombe, N. Moustaid-Moussa // Adv. Nutr. — 2011. — Vol. 2. — P. 304–316.

Omega-3 fatty acids attenuate systemic and adipose imflammatory chemokine responses to evoked imflammation in humans [Електронний ресурс] / R. Shan, J. F. Ferguson, C. C. Hinkle [et al.] // 72nd Scientific sessions of American Diabetes

Association, 8–12 June 2012, Philadelphia, USA. — Abstract 1676-P. — 1 електрон. опт. диск (CDROM).

Human dentritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic, mainly through PPARγ: RXR heterodimers: comparison with other polyunsaturated fatty acids [Text] / Gonzalez Z. F., Rueda F., Petriz J. [et al.] // J. Leuk.

Bio. — 2008. — Vol. 84. — P. 1172–1182.

White, P. J. Is omega-3 key to unlocking inflammation in obesity? [Text] / P. J. White, A. Marette // Diabetologia. — 2006. — Vol. 49. — P. 1999–2001.

Moreno-Aliaga, M. J. Regulation of adipokine secretion by n-3 fatty acids [Text] / M. J. Moreno-Aliaga,S. Lorente-Cebrián, J. A. Martínez // Proceedings of the Nutrition Society. — 2010. — Vol. 69. — P. 324–332.

Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-alpha [Text] / P. Perez-Matute, N. PerezEcharri, J. A. Martinez [et al.] // Br. J. Nutr. —

— Vol. 97. — P. 389–398.

Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet [Text] / P. Flachs, V. Mohamed-Ali, O. Horakova[et al.] // Diabetologia. — 2006. — Vol. 49. — P. 394–397.

Eicosapentaenoic fatty acid increases leptin secretion from primary cultured rat adipocytes: role of glucose metabolism [Text] / P. PerezMatute, A. Marti, J. A. Martinez [et al.] // Am. J. Physiol. Regul. Integr. Comp. Physiol. — 2005. — Vol. 288. — P. R1682–1688.

Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects [Text] / M. Itoh, T. Suganami, N. Satoh [et al.] // Arterioscler. Thromb. Vasc. Biol. — 2007. — Vol. 27. — P. 1918–1925.

The effect of omega-3 on the serum visfatin concentration in patients with type II diabetes [Text] / H. Hajianfar, M. J. Hosseinzadeh, A. Behonar [et al.] // J. Res. Med. Sci. — 2011. — Vol. 16, № 4. — P. 490–495.

Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women [Text] / C. S. Mantzoros, C. J. Williams, J. E. Manson [et al.] // Am. J. Clin. Nutr. — 2006. — Vol. 84. — P. 328–335.

Positive association of dietary polyunsaturated fatty acids intake with plasma adiponectin in subjects with different degrees of glucose tolerance [Електронний ресурс] / A. D. von Frankenberg, V. Piccoli, A. Loctelli Smith [et al.] // 72nd Scientific sessions of American Diabetes Assoaciation, 8–12 June 2012, Philadelphia, USA. — Abstract 741-P. — 1 електрон. опт. диск (CD-ROM).

Eicosapentaenoic acid prevents and reverses insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation [Text] / N. S. Kalupahana, K. Claycombe, S. J. Newman [et al.] // J. Nutr. — 2010. — Vol. 140. —

P. 1915–1922.

Conjugated linoleic acid inhibits glucose metabolism, leptin and adiponectin secretion in primary cultured adipocytes [Text] / P. PerezMatute, A. Marti, J. A. Martinez [et al.] // Mol. Cell. Endocrinol. — 2007. — Vol. 268. — P. 50–58.

Fernandez-Real, J. M. Circulating adiponectin and plasma fatty acid profile [Text] / J. M. FernandezReal, J. Vendrell, W. Ricart // Clin. Chem. — 2005. — Vol. 51. — P. 603–609.

Effect of dietary n-3-polyunsaturated fatty acids on plasma total and high molecular weight adiponectin concentrations in overweight to moderately obese men and women [Text] / M. Kratz, M. M. Swarbrick, H. S. Callahan [et al.] // Am. J. Clin. Nutr. — 2008. — Vol. 87. — P. 347–353.

Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats [Text] / A. S. Rossi, Y. B. Lombardo, J.- M. Lacorte [et al.] // Am. J. Physiol. Regul. Integr. Comp. Physiol. — 2005. — Vol. 289. — P. R486-

R494.

Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice [Text] / S. Neschen, K. Morino, J. C. Rossbacher [et al.] // Diabetes. — 2006. — Vol. 55. — P. 924–928.

Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men [Text] / P. PerezMartinez, J. Lopez-Miranda, C. Cruz-Teno [et al.] // J. Nutr. — 2008. — Vol. 38. — P. 1609–1614.

Effects of seafood consumption and weight loss on fasting leptin and ghrelin concentrations in overweight and obese European young adults [Text] / A. Ramel, D. Parra, J. A. Martinez [et al.] // Eur. J. Nutr. — 2009. — Vol. 48. — P. 107–114.

Effects of fatty acid regulation on visfatin gene expression in adipocytes [Text] / Y. Wen, H.W. Wang, J. Wu [et al.] // Chin. Med. J. (Engl.). — 2006. — Vol. 119. — P. 1701–1708.

Effects of eicosapentaenoic acid ethyl ester on visfatin and apelin in lean and overweight (cafeteria diet-fed) rats [Text] / N. Perez-Echarri, P. PerezMatute, B. Marcos-Gomez [et al.] // Br. J. Nutr. — 2009. — Vol. 101. — P. 1059–1067.

Omega-3 fatty acids for cardioprotection [Text] / J. H. Lee, J. H. O’Keefe, C. J. Lavie [et al.] // Mayo. Clin. Proc. — 2008. — Vol. 83. — P. 324–332.

Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake [Text] / A. Leaf, C. M. Albert, M. Josephson [et al.]; Fatty Acid Antiarrhythmia Trial Investigators // Circulation. — 2005. — Vol. 112. — P. 2762–2768.

Rationale and design of a randomised controlled clinical trial on supplemental intake of n-3 fatty acids and incidence of cardiac arrhythmia: SOFA [Text] / I. A. Brouwer, P. L. Zock, E. F. Wever [et al.] // Eur. J. Clin. Nutr. — 2003. — Vol. 57. — P. 1323–1330.

Left ventricular systolic dysfunction, total mortality, and sudden death in patients with myocardial infarction treated with n-3 polyunsaturated fatty acids [Text] / A. Macchia, G. Levantesi, M. G. Franzosi [et al.] // Eur. J. Heart. Fail. — 2005. — Vol. 7. — P. 904–909.

n-3 Fatty acids, ventricular arrhythmia-related events, and fatal myocardial infarction in postmyocardial infarction patients with diabetes [Text] / D. Kromhout, J. M. Gelejnse, J. de Goede [et al.] // Diabetes Care. — 2011. — Vol. 34. — P. 2515–2520.

Suppressive effect of EPA on the incidence of coronary events in hypercholesterolemia with impaired glucose metabolism: Sub-analysis of the Japan EPA Lipid Intervention Study (JELIS) [Text] / S. Oikawa, M. Yokoyama, H. Origasa [et al.]

// Atheroscler. — 2009. — Vol. 206. — P. 535–539.

Fish and long-chain ω-3 fatty acid intake and risk of coronary heart disease and total mortality in diabetic women [Text] / F. B. Hu, E. Cho, K. M. Rexrode [et al.] // Circulation. — 2003. — Vol. 107. — P. 1852–1857.

Fish and shellfish consumption in relation to death from myocardial infarction among men in Shanghai, China [Text] / J. M. Yuan, R. K. Ross, Y. T. Gab, M. M. C. Yu // Am. J. Epidemiol. — 2001. — Vol. 154. — P. 809–816.

Marik, P. E. Omega-3 dietary supplements and the risk of cardiovascular events: a systematic review [Text] / P. E. Marik, J. Varon // Clin. Cardiol. — 2009. — Vol. 32. — P. 365–372.

n-3 Polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials [Text] / H. C. Bucher, P. Hengstler, C. Schindler [et al.] // Am. J. Med. — 2002. — Vol. 112. — P. 298–304.

Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man [Text] / D. R. Matthews, J. P. Hosker, A. S. Rudenski [et al.] // Diabetologia. — 1985. — Vol. 28. —

P. 412–419.

Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans [Text] / A. Katz, S. S. Nambi, K. Mather [et al.] // J. Clin. Endocrinol. Metabol. — 2000. — Vol. 85. — P. 2402–2410.

Omega-3 polyunsaturated fatty acids attenuated insulin resistance in type 2 diabetes patients [Text] / Y. Karachentcev, M. Gorshunska, E. Jansen [et al.] // World Diabetes Congress, Dubai, 4–8 December, 2011. — Dubai, 2011. — P. 458.

Omega-3 polyunsaturated fatty acids attenuated insulin resistance in type 2 diabetes patients [Text] / Y. Karachentcev, M. Gorshunska, E. Jansen [et al.] // The 2nd Latin America Congress on Controversies in Diabetes, Obesity and Hypertension, Riode-Janeiro, 22–25 March, 2012. — Rio-de-Janeiro, 2012. — P. 19A.

Downloads

Published

2012-12-25

How to Cite

Gorshunska, M. (2012). EFFECT OF OMEGA-3 POLYUNSATURATED FATTY ACIDS ON CLASSIC AND NOVEL CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS (review and our own results). Problems of Endocrine Pathology, 42(4), 126-137. https://doi.org/10.21856/j-PEP.2012.4.19

Most read articles by the same author(s)

1 2 > >>