ABOUT THE MECHANISMS OF CARBOHYDRATE METABOLISM DESORDERS IN PATIENTS WITH ACROMEGALY

Authors

DOI:

https://doi.org/10.21856/j-PEP.2012.3.03

Keywords:

acromegaly, growth hormone, insulin-like growth factor-1, prolactin, diabetes mellitus, insulin-resistance, hyperinsulinemy

Abstract

Investigation of the carbohydrate methabolism was done in 97 patients with active acromegaly
including 21 de novo acromegaly patients. Effects of growth hormone, insulin-like growth factor-1 and
prolactin on sensitivity to insulin and β-sell function were determined due to analysis of associations
of those hormones with insulin and HOMA indices. The role of permanent hypersomatotropinemy in
the pathogenesis of insulin-resistance and compensatory hyperinsulinemy in patients with acromegaly
was discussed.

References

Гарднер, Д. Базисная и клиническая эндокринология. Книга 1 [Текст] / Пер. с англ. — М.: Издательство БИНОМ, 2010. — С. 132–197.

Курляндская, Р. М. Роль гормона роста в регуляции жирового и углеводного обмена [Текст] / Р. М. Курляндская, Т. И. Pоманцова // Лечащий врач. — 2002. — № 5. — С. 36–38.

Secondary diabetes associated with principal endocrinopathies: the impact of new treatment modalities. [Text] / E. Resmini, F. Minuto, A. Colao, D. Ferone / Acta Diabetol. — 2009. — Vol. 46, № 2. — P. 85–95.

Дедов, И. И. Акромегалия: патогенез, клиника, диагностика, дифференциальная диагностика, методы лечения [Teкст]: пособие для врачей / И. И. Дедов, Н. Н. Молитвословова, Е. И. Марова. — Тверь: Изд-во «Триада», 2003. — 40 с.

Insulin resistance and insulin secretion in non-diabetic acromegalic patients. [Text] / M. Coculescu, D. Niculescu, R. Lichiardopol, M. Purice / Exp. Clin. Endocrinol. Diabetes. — 2007. — Vol. 115, № 5. — P. 308–316.

Kovacs, P. Fatty acids and insulin resistance in muscle and liver [Text] / P. Kovacs, M. Stumvoll // Best Pract. Res. Clin. Endocrinol. Metabol. — 2005. — Vol. 19, № 4. — P. 625–635.

Lebrun, P. SOCS proteins causing trouble in insulin action [Text] / P. Lebrun, E. Van Obberghen // Acta Physiol. (Oxf). — 2008. — Vol. 192, № 1. — P. 29–36.

Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance [Text] / J. P. del Rincon, K. Iida, B. D. Gaylinn [et al.] // Diabetes. — 2007. — Vol. 56,

№ 6. — 1638–1646.

AcroBel — the Belgian registry on acromegaly: a survey of the ‘real-life’ outcome in 418 acromegalic subjects [Text] / M. Bex, R. Abs, G. T’Sjoen [et al.] // Europ. J. Endocrinol. — 2007. — Vol. 157. — P. 399–409.

Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol de Acromegalia, REA) [Text] / A. Mestron, S. Webb, R. Astorga [et al.] / Europ. J. Endocrinol. — 2004. — Vol. 151, № 4. — P. 439–446.

Holdaway, I. M. Factors influencing mortality in acromegaly [Text] / I. M. Holdaway, R. C. Rajasoorya, G. D. Gamble // J. Clin. Endocrinol. Metabol. — 2004. — Vol. 89. — P. 667–674.

Criteria for Cure of Acromegaly: A Consensus Statement [Text] / A. Giustina, A. Barkan, F. F. Casanueva, F. Cavagnini // J. Clin. En-

docrinol. Metabol. — 2000. — Vol. 85, № 2. — P. 526–529.

Электронний ресурс www.dtu.ox.ac.uk/homacalculator/index.php

Kahn, C. R. Role of insulin receptors in insulinresistant states [Text] // Metabolism. — 1980. — Vol. 29, № 5. — P. 455–466.

Samuel, V. T. Mechanisms for insulin resistance: common threads and missing links [Text] / V. T. Samuel, G. I. Shulman // Cell. — 2012. — Vol. 148, № 5. — P. 852–871.

Wallace T. M. Use and abuse of HOMA modeling [Text] / T. M. Wallace, J. C. Levy, D. R. Matthews // Diabetes Care. — 2004. — Vol. 27. — № 6. — P. 1487–1495.

Accurate assessment of β -cell function: the hyperbolic correction [Text] / R. N. Bergman, M. Ader, K. Huecking [et al.] // Diabetes. — 2002. — Vol. 51, Suppl. 1. — P. S212–S220.

Ожирение: этиология, патогенез, клинические аспекты [Текст] / Под ред. И. И. Дедова, Г. А. Мельниченко. — М.: Медицинское информационное агентство, 2004. — С. 84–88.

Downloads

Published

2012-10-10

How to Cite

Mykytyuk, M. (2012). ABOUT THE MECHANISMS OF CARBOHYDRATE METABOLISM DESORDERS IN PATIENTS WITH ACROMEGALY. Problems of Endocrine Pathology, 41(3), 21-27. https://doi.org/10.21856/j-PEP.2012.3.03

Issue

Section

CLINICAL ENDOCRINOLOGY