ABOUT THE MECHANISMS OF CARBOHYDRATE METABOLISM DESORDERS IN PATIENTS WITH ACROMEGALY

Authors

DOI:

https://doi.org/10.21856/j-PEP.2012.3.03

Keywords:

acromegaly, growth hormone, insulin-like growth factor-1, prolactin, diabetes mellitus, insulin-resistance, hyperinsulinemy

Abstract

Investigation of the carbohydrate methabolism was done in 97 patients with active acromegaly
including 21 de novo acromegaly patients. Effects of growth hormone, insulin-like growth factor-1 and
prolactin on sensitivity to insulin and β-sell function were determined due to analysis of associations
of those hormones with insulin and HOMA indices. The role of permanent hypersomatotropinemy in
the pathogenesis of insulin-resistance and compensatory hyperinsulinemy in patients with acromegaly
was discussed.

References

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Published

2012-10-10

How to Cite

Mykytyuk, M. (2012). ABOUT THE MECHANISMS OF CARBOHYDRATE METABOLISM DESORDERS IN PATIENTS WITH ACROMEGALY. Problems of Endocrine Pathology, 41(3), 21-27. https://doi.org/10.21856/j-PEP.2012.3.03

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Section

CLINICAL ENDOCRINOLOGY

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