THE ROLE OF OBESIT Y IN THE DE VELOPMENT OF VITAMIN D DEFICIENCY RICKETS IN CHILDREN

Authors

  • Puhach М. М. National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • Kolesnyk V. P. Kharkiv National Medical University, Kharkiv, Ukraine
  • Herasymova O. V. National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • Mazur O. H. National Pirogov Memorial Medical University, Vinnytsya, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2021.2.15

Keywords:

vitamin D deficiency rickets, obesity

Abstract

Vitamin D deficiency rickets is one of the most common diseases among children of the first years of life in many countries around the world. It is very important to understand the aforementioned nosological unit as a metabolism disorder, and not just as a D-deficiency state. In modern conditions, the risk factors for vitamin D deficiency rickets have undergone further study. The results of the research indicate that obesity is one of the risk factors for vitamin D deficiency in children. Thus, vitamin D metabolism, deposition, bioavailability and its biological role are dependent on the size of adipose tissue. The pathogenetic interaction between obesity andМvitamin D deficiency is probably predetermined by several mechanisms. Firstly, in case of obesity, vitamin D,Мwhich is a fat-soluble substance, is distributed in a considerable amount of adipose tissue, which leads to
a decrease in its concentration in the blood plasma. Secondly, with excessive body weight there is a limitation of vitamin D bioavailability, caused by vitamin D capture with adipocytes and depositing in adipose tissue.
Thirdly, there is a genetic proof that the increase in BMI leads to a decrease in vitamin D levels in blood serum.
Recent studies have shown that adipose tissue may be the direct target of vitamin D physiological actions.
It has been proved that vitamin D can affect obesity through numerous mechanisms, including protein expression, oxidative stress, inflammation and cellular metabolism. Currently, recommendations for treatment and prevention of vitamin D deficiency can be found in international foreign guidebooks whose authors state that obese children need a higher dosage of vitamin D compared to those whose physical development is consistent with age. Understanding the influence of adipose mass on bone tissue during its growth and development is a very important aspect for further health and pharmacotherapy strategies to prevent bone disorders.

References

Kimball SM, Holick MF. Eur J Clin Nutr 2020; 74(11):151-1518. https://doi.org/10.1038/s41430-020-00706-3.

Gonzalez Nguyen-Tang E, Parvex P, Goischke A, Wilhelm-Bals A. Rev Med Suisse 2019;5: 384-389.

Hlebovets NI. Zhurn Grodnenskogo Gos Med Un-ta 2011;3: 51-54.

Migliaccio S, Di Nisio А, Mele C, et al. Int J Obes 2019;9(1): 20-31. https://doi.org/10.1038/s41367-019-0010-8.

Zelinska NB. Klin Endokrynol Endokryn Khirurhiia 2013;4(45): 62-72.

Hugler W. Best Pract Res Clin Endocrinol Metab 2015;29(3): 385-398. https://doi.org/10.1016/j.beem.2015.03.003.

Belyaeva LM, Nevero EG, Kolupaeva EA. Meditsinskie Novosti 2008;14: 17-22.

Fiamenghi VI, Mello ED. J Pediatr 2020; 96(6): 1-7. https://doi.org/10.1016/j.jped.2020.08.006.

Chanchlani R, Nemer P, Sinha R, et al. Kidney Int Rep 2020;5(7): 980-990. https://doi.org/10.1016/j.ekir.2020.03.025.

Antonucci R, Locci C, Clemente MG, et al. J Pediatr Endocrinol Metab 2018;31(3): 247-260. https://doi.org/10.1515/jpem-2017-0391.

Walsh JS, Bowles S, Evans AL. Curr Opin Endocrinol Diab Obes 2017;24(6): 389-394. https://doi.org/10.1097/MED.0000000000000371.

Ekwaru JP, Zwicker JD, Holick MF, et al. PLoS One 2014;9(11): e111265. https://doi.org/10.1371/journal.pone.0111265.

Lagunova Z, Porojnicu AC, Lindberg FA, et al. Pediatr Diab 2011;12(2): 120-1266. https://doi.org/10.1111/j.1399-5448.2010.00672.x.

Turer CB, Lin H, Flores G. Pediatrics 2013; 131(1): 152-161. https://doi.org/10.1542/peds.2012-1711.

Bellone S, Esposito S, Giglione E, et al. J Endocrinol Invest 2014;37(9): 805-809. https://doi.org/10.1007/s40618-014-0108-3.

Nunlee-Bland G, Gambhir K, Abrams C, et al. J Pediatr Endocrinol Metab 2011;24(1-2): 29-33. https://doi.org/10.1515/jpem.2011.107.

Oliveira RM, Novaes JF, Azeredo LM, et al. Public Health Nutr 2014;17(4): 787-794. https://doi.org/10.1017/S1368980013001225.

Khor GL, Chee WS, Shariff ZM, et al. BMC Public Health 2011;11(95): 1-8. https://doi.org/10.1186/1471-2458-11-95.

Rojas LZ, Quintero-Lesmes DC, Gamboa-Delgado EM, et al. J Nutr Sci 2020;9: e55. https://doi.org/10.1017/jns.2020.47.

Rajakumar K, de las Heras J, Chen TC, et al. J Clin Endocrinol Metab 2011;96(5): 1560-1567. https://doi.org/10.1210/jc.2010-2388.

Sioen I, Mouratidou T, Kaufman JM, et al. Publ Health Nutr 2012;15(6): 1093-1099. https://doi.org/10.1017/S1368980011002989.

Midtbo LK, Nygaard LB, Markhus MW, et al. Nutrition 2020;70: 110595. https://doi.org/10.1016/j.nut.2019.110595.

Dmitrieva YA. Faktoryi riska i osobennosti techeniya rahita u detey rannego vozrasta v sovremennyih usloviyah, Мoscow, 2011: 24 р.

Romacho T, Elsen M, Ruhrborn D, et al. Acta Physiologica 2014;210(4): 733-753. https://doi.org/10.1111/apha.12246.

Vinh quốc Lương K, Nguyễn LT. Nutr J 2013;12(89): 1-12. https://doi.org/10.1177/1533317512473196.

Gao D, Trayhurn P, Bing C. Int J Obes 2013; 37(3): 357-365. https://doi.org/10.1038/ijo.2012.53.

Ding C, Gao D, Wilding J, et al. Br J Nutr 2012;108(11): 1915-1923. https://doi.org/10.1017/S0007114512003285.

De Paula FJA, Rosen CJ. Vitamin D and fat. In: Vitamin D; Feldman D, Pike JW, Adams JS, Academic Press, 2011: 769-776.

Cao JJ. J Orthopaedic Surg Res 2011;6(1): 30-37. https://doi.org/10.1186/1749-799X-6-30.

Płudowski P, Karczmarewicz E, Bayer M, et al. Endokrynol Polska 2013;64(3): 238-246. https://doi.org/10.5603/EP.2013.0012.

Saliba W, Barnett-Griness О, Rennert G. Osteoporosis Int 2013;24(4): 1447-1454. https://doi.org/10.1007/s00198-012-2129-0.

Roosta S, Kharadmand Mina, Teymoori F, et al. Diabetol Metab Syndr 2018;2(4): 537-541. https://doi.org/10.1016/j.dsx.2018.03.022.

Earthman CP, Beckman LM, Masodkar K, et al. Int J Obes 2012;36(3): 387-396. https://doi.org/10.1038/ijo.2011.119.

Saida FB, Chen X, Tran K, et al. Exp Rev Mol Diagnost 2015;15(3): 313-323. https://doi.org/10.16966/2572-9578.132.

Yazdanpanah M, Bailey D, Walsh W, et al. Clin Biochem 2013;46(13-14): 1264-1271. https://doi.org/10.1016/j.clinbiochem.2012.11.030.

Audran M, Briot K. Revue du Rhumatisme 2010;77(2): 139-143. https://doi.org/10.1016/j.rhum.2009.09.009.

Bischoff-Ferrari H. Int J Vitamin Nutr Res 2012;82(5): 321-326. https://doi.org/10.1024/0300-9831/a000126.

Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. J Clin Endocrinol Metab 2011;96(7): 1911-1930. https://doi.org/10.1210/jc.2011-0385.

Gуmez de Tejada Romero MJ, Sosa Henrнquez M, Del Pino Montes J, et al. Rev Osteoporos Metab Mineral 2011;3(1): 53-64.

Vieth R. Clin Endocrinol Metab 2011;25(4): 681-691. https://doi.org/10.1016/j.beem.2011.06.009.

Torun E, Gonullu E, Ozgen IT, et al. Int J Endocrinol 2013: 631845. https://doi.org/10.1155/2013/631845.

Halicioglu О, Sutcuoglu S, Koc F, et al. Pediatrics 2012;130(4): 921-927. https://doi.org/10.1542/peds.2012-0017.

Priemel M, Von Domarus C, Klatte TO, et al. J Bone Mineral Res 2010;25(2): 305-312. https://doi.org/10.1359/jbmr.090728.

Heaney RP, Holick MF. J Bone Mineral Res 2011;26(3): 455-457. https://doi.org/10.1002/jbmr.328.

Ebeling PR. Bonekey Rep 2014;3(511): 1-5. https://doi.org/10.1038/bonekey.2014.6.

Bouillon R, Van Schoor NM, Gielen E, et al. J Clin Endocrinol Metab 2013;98(8): 1283-1304. https://doi.org/10.1210/jc.2013-1195.

Paxton GA, Teale GR, Nowson CA, et al. Med J Australia 2013;198(3): 142-143. https://doi.org/10.5694/mja11.11592.

Chao YS, Brunel L, Faris P, Veugelers PJ. Nutrients 2013;5(10): 4067-4078. https://doi.org/10.3390/nu5104067.

Turkina TI, Scherbakova MY. Ratsionalnaya Farmakoterapiya v Kardiologii 2011;7(1): 65-69.

Birken CS, Lebovic G, Anderson LN, et al. PLoS One 2015; 0(7): e0131938. https://doi.org/10.1371/journal.pone.0131938.

Arnberg K, Ostergеrd M, Madsen AL, et al. Acta Paediatrіса 2011;100(9): 1244-1248. https://doi.org/10.1111/j.1651-2227.2011.02273.x.

Kolesnyk PO, Kolesnyk AP, Tsiapets HB, Svereniak HM. Visn Probl Biolohii i Medytsyny 2014;110(3): 169-172.

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Published

2021-06-10

How to Cite

Puhach М. М., Kolesnyk, V. P., Herasymova, O. V., & Mazur, O. H. (2021). THE ROLE OF OBESIT Y IN THE DE VELOPMENT OF VITAMIN D DEFICIENCY RICKETS IN CHILDREN. Problems of Endocrine Pathology, 76(2), 109-116. https://doi.org/10.21856/j-PEP.2021.2.15