ЕFFECTS OF LONG-TERM PASSIVE PARENTAL SMOKING ON THE CONDITION OF THE WOUND PROCESS, ADRENAL GLANDS AND CORTICOSTERONE LEVELS IN THE OFFSPRING OF FEMALE RATS

Authors

  • Tkachenko V. M. Kharkiv Specialized School of I–III grades № 134, Kharkiv, Ukrain
  • Komisova T. E. Kharkiv National Pedagogical University named after G. S. Skovoroda, Kharkiv, Ukraine
  • Halii A. I. Kharkiv National Pedagogical University named after G. S. Skovoroda, Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2021.2.14

Keywords:

adrenal glands, corticosterone, mechanical wound, passive smoking.

Abstract

The adaptation of the organism to changes in various environmental factors is due to the system of stress reactions, which determines the individual reactivity of the organism and its adaptive capabilities. However, the imbalance of the neuroendocrine system caused by the action of negative factors in the early stages of ontogenetic development of the organism can lead to various functional disorders. One of the widespread factors in modern life, which negatively affects the reactivity of offspring, is parental smoking. Researching the parental smoking effects during pregnancy on the stress reactivity of offspring in the early postnatal period is the current issue today.

The aim of the study was to investigate the content of corticosterone and the state of the wound process in the offspring of first-generation females on the background of passive parental smoking.

During the research, it was found that in response to painful stress irritation (mechanical wound), the level of corticosterone in the blood plasma of the rat offspring to the background of parental passive smoke was multidirectional and determined which of the “parent” rats smoked and nicotine and tar content in cigarettes.

In the rat offspring groups, where both male and female were smoked cigarettes with a filter (PMB24, PMB48), the level of corticosterone increased statistically significantly by 19 %      (≤ 0.05) and 18 % (≤ 0.05), respectively, compared with the groups K24, K48. In the rat offspring groups where only male was smoked cigarettes with a filter (PB24, PB48) and male and female were smoked cigarettes without a filter, the level of corticosterone was statistically significantly lower than the control values by 16 % (≤ 0.05) and 18 % (≤ 0.05) compared with groups K24 and K48. The decreases in corticosterone was also observed in the groups VMB24, VMB48 by 9 % (≤ 0.05) and 15 % (≤ 0.05), accordingly.

Such corticosterone imbalances in female offspring are likely related to the effects of tobacco smoke components on rat parents (male and female) at the time of fertilization and embryogenesis. The consequences of the rats prenatal stress were displayed by a violation of the inflammatory phase of the mechanical wound in the postnatal period, which indicates a decrease in their reactivity to the stress stimulus action.

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Published

2021-06-10

How to Cite

Ткаченко, В. М., Комісова, Т. Є., & Галій, А. І. (2021). ЕFFECTS OF LONG-TERM PASSIVE PARENTAL SMOKING ON THE CONDITION OF THE WOUND PROCESS, ADRENAL GLANDS AND CORTICOSTERONE LEVELS IN THE OFFSPRING OF FEMALE RATS. Problems of Endocrine Pathology, 76(2), 102-108. https://doi.org/10.21856/j-PEP.2021.2.14