THE VALUE OF sCD40L IN PREDICTING THE DEVELOPMENT OF CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND ARTERIAL HYPERTENSION

Authors

  • Kadykova O. I. Kharkiv National Medical University

DOI:

https://doi.org/10.21856/j-PEP.2012.4.06

Keywords:

sCD40L, type 2 diabetes mellitus, arterial hypertension, cardiovascular complication

Abstract

The value of sCD40L and presence of cardiovascular complications were examined based on the investigation of 56 patients with type 2 diabetes mellitus and arterial hypertension. The level of sCD40L was increase in patients with diabetes mellitus. The mathematical model for prediction the development of cardiovascular complications has shown the value of sCD40L as a marker of cardiovascular risk.

References

Зв’язок комплаєнсу при лiкуваннi артерiальної гiпертензiї з психологiчними чинниками особистостi [Текст] / К. М. Амосова, Л. Є. Трачук, Н. В. Береза, Ю. В. Руденко // Серце i судини. — 2012. — № 1. — С. 85–92.

Сакалош, В.Ю. Першi пiдсумки всеукраїнського проекту для лiкарiв «Серцево-судинний ризик пiд контролем» [Текст] / В.Ю. Сакалош // Медiкс. Антиейджинг. — 2010. — № 2. — С. 40–42.

Бiловол, О. М. Основи дiагностики, лiкування та профiлактики основних кардiологiчних захворювань [Текст] / О. М. Бiловол, П. Г. Кравчун // Учбовий посiбник для студентiв V курсу медичних ВУЗiв IV рiвня акредитацiї: Харкiв, ХНМУ. —

— Ч. 1. — 402 с.

The role of inflammation on atherosclerosis, intermediate and clinical cardiovascular endpoints in type 2 diabetes mellitus [Text] / A. Ray, M. V. Huisman, J. T. Tamsma [et al.] // Europ. J. Intern. Med. — 2009. — № 20 (3). — P. 253–260.

The CD40/CD154 receptor/ligand dyad [Text] / U. Schönbeck, P. Libby // Cell. Mol. Life Sci. — 2001. — № 58. — P. 4–43.

Upregulation of CD40–CD40 ligand system in patients with diabetes mellitus [Text] / Y. Jinchuan, W. Zonggui, C. Jinming [et al.] // Clin. Chim. Acta. — 2004. — № 339 (1–2). — P. 85–90.

Enhanced soluble CD40 ligand contributes to endothelial cell dysfunction in vitro and monocyte activation in patients with diabetes mellitus: effect of improved metabolic control [Text] / F. Cipollone, F. Chiarelli, G. Davi, [et al.] // Diabetologia. —

— № 48 (6). — P. 1216–1224.

CD40 лиганд у больных ишемической болезнью сердца в сочетании с сахарным диабетом 2 типа [Текст] / О. П. Шевченко, О. Ф. Природова, О. В. Орлова, А. О. Шевченко // Росс. кардиол. журн. — 2006. — № 5. — С. 23–28.

Effect of atorvastatin on soluble CD14, CD40 Ligand, sEand sP-selectins and MCP-1 in patients with type 2 diabetes mellitus: relationship to cholesterol turnover [Text] / V. Bláha, C. Andrýs, A. Smahelová [et al.] // Pharmacol. Res. — 2006. — № 54

(6). — P. 421–428.

Soluble Pselectin and CD40L levels in subjects with prediabetes, diabetes mellitus, and metabolic syndrome-the Chennai Urban Rural Epidemiology Study [Text] / K. Gokulakrishnan, R. Deepa, V. Mohan, M. D. Gross // Metabolism. — 2006. — № 55

(2). — P. 237–242.

Effects of different LDL particles on inflammatory molecules in human mesangial cells [Text] / E. Santini, R. Lupi, S. Baldi [et al.] // Diabetologia. — 2008. — № 51 (11). — P. 2117–2225.

Enhanced levels of soluble CD40 ligand and C-reactive protein in a total of 312 patients with metabolic syndrome [Text] / I. T. Unek, F. Bayraktar, D. Solmaz [et al.] // Metabolism. — 2010. — № 59 (3). — P. 305–313.

Downloads

Published

2012-12-25

How to Cite

Kadykova, O. I. (2012). THE VALUE OF sCD40L IN PREDICTING THE DEVELOPMENT OF CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND ARTERIAL HYPERTENSION. Problems of Endocrine Pathology, 42(4), 36-40. https://doi.org/10.21856/j-PEP.2012.4.06

Issue

Section

CLINICAL ENDOCRINOLOGY

Most read articles by the same author(s)