THE FE ATURES OF THE MICROCIRCUL ATION DISORDERS BY METABOLIC SYNDROME DEPENDING ON THE COMBINATION OF THE COMPONENTS IN THE ELDERLY

Authors

  • Korkushko O. V. The State Institution «D. F. Chebotarev Institute of Gerontology NAMS Ukraine», Kiev, Ukraine
  • Nikolaiev R. S. The State Institution «D. F. Chebotarev Institute of Gerontology NAMS Ukraine», Kiev, Ukraine
  • Shatilo V. B. The State Institution «D. F. Chebotarev Institute of Gerontology NAMS Ukraine», Kiev, Ukraine
  • Chyzhova V. P. The State Institution «D. F. Chebotarev Institute of Gerontology NAMS Ukraine», Kiev, Ukraine
  • Safonova М. I. The State Institution «D. F. Chebotarev Institute of Gerontology NAMS Ukraine», Kiev, Ukraine
  • Samots I. A. The State Institution «D. F. Chebotarev Institute of Gerontology NAMS Ukraine», Kiev, Ukraine
  • Duzak G. V. The State Institution «D. F. Chebotarev Institute of Gerontology NAMS Ukraine», Kiev, Ukraine
  • Kovtonyuk T. I. The State Institution «D. F. Chebotarev Institute of Gerontology NAMS Ukraine», Kiev, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2021.2.06

Keywords:

metabolic syndrome, pre-diabetes, microcirculation, blood viscosity, platelet aggregation.

Abstract

How many components of the metabolic syndrome are very important to understanding about risk factors for cardiovascular disease and progression of previous diseases of the cardiovascular system and system of microcirculation. Impaired glucose tolerance and impaired fasting glucose form is intermediate stages in the
natural history of diabetes mellitus. The risk of early death from cardiovascular diseases in patients with intermediate stages of diabetes mellitus in several times higher than risk in healthy people. At the same time, the mechanisms of mutual aggravated influence of metabolic syndrome and pre-diabetes disorders on the features of the microcirculation didn’t sufficiently studied today. The aim of this study is to understanding what features of the microcirculatory disorders by metabolic syndrome is depended of different glucose level in the elderly. For this goal 142 people were examined. Due of the combination of components of the metabolic syndrome and pre-diabetes disorders all patients were divided into different groups. The most severe disorders of glucose metabolism and microcirculatory function were founded in group of patients with a combination of 3–5 symptoms (hypertension, pre-diabetes, obesity and dyslipidemia). The most of patients were in 60 age and over group. The patients of this group were characterized by significant higher glucose level and microcirculatory disorders. The negative effect on the microvessels parameters and risk of the hypercoagulation influence for pre-diabetes state were noted in patients 40–59 years old and more higher in elderly people. The negative effect on the microvessels parameters and higher risk of the hypercoagulation were noted in patients 40–59 years old and more higher in elderly people who have pre-diabetes status. The formation of pre-diabetes with metabolic syndrome is depends from their components. Given the presence of pre-diabetic changes in the background of the metabolic syndrome, the identified changes in microcirculation can be understood as early manifestations of microangiopathy long before the development of diabetes mellitus and its life-threatening vascular complications.

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Published

2021-06-10

How to Cite

Коркушко, О. В., Ніколаєв, Р. С., Шатило, В. Б., Чижова, В. П., Сафонова, М. І., Самоць, І. А., Дужак, Г. В., & Ковтонюк, Т. І. (2021). THE FE ATURES OF THE MICROCIRCUL ATION DISORDERS BY METABOLIC SYNDROME DEPENDING ON THE COMBINATION OF THE COMPONENTS IN THE ELDERLY. Problems of Endocrine Pathology, 76(2), 41-48. https://doi.org/10.21856/j-PEP.2021.2.06

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